State Key Laboratory of Reproductive Medicine, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China; Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.
State Key Laboratory of Reproductive Medicine, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China; Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.
J Hazard Mater. 2020 May 5;389:122152. doi: 10.1016/j.jhazmat.2020.122152. Epub 2020 Jan 21.
Glufosinate ammonium (GLA) is a widely used organophosphate herbicide, which could be commonly detected in body fluids of both pregnant women and newborns. Existing evidences indicate that GLA has reproductive toxicity, while data concerning the effects of prenatal GLA exposure on neurodevelopment is rather limited. Here we employed a mouse model exposed to GLA prenatally. Reduced locomotor activity, impaired memory formation and autism-like behaviors were observed in the treatment group. Marked alteration in gut microbiome of the treatment offspring mice could be found at 4th week, and seemed to recover over time. Fecal metabolomics analysis indicated remarkable changes in microbiome-related metabolism in the treatment group, which could be the cause of behavioral abnormality in mice. Present study suggested that prenatal exposure to GLA disturbed gut microbiome and metabolism, and thereby induced behavioral abnormalities in mice.
草铵膦（GLA）是一种广泛使用的有机磷除草剂，在孕妇和新生儿的体液中都能被普遍检测到。现有证据表明 GLA 具有生殖毒性，而关于产前 GLA 暴露对神经发育影响的数据则相当有限。本研究采用了一种产前暴露于 GLA 的小鼠模型。结果显示，处理组的小鼠运动活性降低，记忆形成受损，出现类似自闭症的行为。在第 4 周时，处理组的子代小鼠肠道微生物组发生了明显改变，且随着时间的推移似乎有所恢复。粪便代谢组学分析表明，处理组的微生物组相关代谢发生了显著变化，这可能是导致小鼠行为异常的原因。本研究表明，产前暴露于 GLA 会扰乱肠道微生物组和代谢，从而导致小鼠出现行为异常。
