Kaczmarczyk Michael, Spitzer Carsten, Wingenfeld Katja, Wiedemann Klaus, Kuehl Linn K, Schultebraucks Katharina, Deuter Christian Eric, Otte Christian
Department of Psychiatry and Psychotherapy, Campus Benjamin Franklin, Charité, Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany.
Department of Psychosomatic Medicine, University Medicine Rostock, Rostock, Germany.
Eur J Psychotraumatol. 2020 Nov 2;11(1):1837511. doi: 10.1080/20008198.2020.1837511.
Adverse childhood experiences (ACE) are associated with an increased risk of major depressive disorder (MDD) and hypothalamic-pituitary-adrenal (HPA) axis dysregulation. Within the HPA axis, corticotropin-releasing hormone and vasopressin (AVP) synergistically stimulate the release of adrenocorticotropic hormone, which promotes cortisol release. The cleavage product copeptin is produced during AVP synthesis and is a surrogate marker of AVP release. Children with ACE and young adults with depressive symptoms have higher levels of copeptin than healthy controls. To uncover the effects of MDD and ACE on copeptin levels in adult females. We recruited 94 women (mean age: 34.0 ± 3.6 years): 23 with MDD and ACE, 24 with MDD without ACE, 22 with ACE without MDD, and 25 healthy controls. ACE was defined as repeated sexual or physical abuse at least once a month over at least one year before the age of 18 years. MDD was defined by the DSM-IV criteria. Copeptin plasma levels were measured with an immunoluminometric assay. The four groups did not differ in demographic variables. We found a significant negative correlation between body mass index (BMI) and copeptin plasma levels ( = -.21; = .045). Copeptin plasma levels did not differ between the four groups after controlling for BMI. Neither MDD nor ACE was associated with altered plasma copeptin levels. Thus, copeptin does not seem to play a major role in MDD and ACE in adult females.
童年不良经历（ACE）与重度抑郁症（MDD）风险增加以及下丘脑-垂体-肾上腺（HPA）轴功能失调相关。在HPA轴内，促肾上腺皮质激素释放激素和血管加压素（AVP）协同刺激促肾上腺皮质激素释放，从而促进皮质醇释放。切割产物 copeptin 在 AVP 合成过程中产生，是 AVP 释放的替代标志物。有 ACE 的儿童和有抑郁症状的年轻人的 copeptin 水平高于健康对照组。为了揭示 MDD 和 ACE 对成年女性 copeptin 水平的影响。我们招募了 94 名女性（平均年龄：34.0 ± 3.6 岁）：23 名患有 MDD 且有 ACE，24 名患有 MDD 但无 ACE，22 名有 ACE 但无 MDD，以及 25 名健康对照。ACE 定义为在 18 岁之前至少一年每月至少遭受一次性虐待或身体虐待。MDD 根据《精神疾病诊断与统计手册第四版》（DSM-IV）标准定义。采用免疫发光法测量 copeptin 血浆水平。四组在人口统计学变量上没有差异。我们发现体重指数（BMI）与 copeptin 血浆水平之间存在显著负相关（r = -0.21；P = 0.045）。在控制 BMI 后，四组之间的 copeptin 血浆水平没有差异。MDD 和 ACE 均与血浆 copeptin 水平改变无关。因此，copeptin 在成年女性的 MDD 和 ACE 中似乎不发挥主要作用。
