Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia.
Department Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, CIpto Mangunkusumo Hospital, Jakarta, Indonesia.
J Nutr Sci. 2020 Nov 11;9:e50. doi: 10.1017/jns.2020.42. eCollection 2020.
Neonatal mortality rates in Indonesia are still at an alarming rate, with preterm birth as one of the causes. Nutritional deficiencies such as low level of vitamin D is suspected to be the risk factors of preterm birth but still a little knowledge about it. Vitamin D metabolism includes 25-hydroxyvitamin D (25(OH)D) and 1,25-dihydroxyvitamin D (1,25(OH)D), as the inactive and active form, with the help of 1α-hydroxylase (CYP27B1) enzyme. Our study aims to determine the differences of 25(OH)D, 1,25(OH)D and CYP27B1 enzyme in term and preterm birth. A cross-sectional study was performed in Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia, in January-June 2017. The blood sample was taken soon after delivery, to examine maternal 25(OH)D and 1,25(OH)D in serum and tissue placenta, as well as placental CYP27B1 enzyme. Statistical analysis using SPPS version 20 was used to find significances. There were a total of sixty subjects in this study, with term-preterm birth group ratio 1:1. We found that placental 25(OH)D was significantly low ( = 0⋅001), and CYP27B1/25(OH)D ratio was high in preterm birth. Also, there were significant negative correlations found in CYP27B1 level and both placental 25(OH)D ( 0⋅481, < 0⋅001) and 1,25(OH)D ( -0⋅365, = 0⋅004) levels. Our study concludes that preterm birth showed lower placental 25(OH)D status, and higher CYP27B1/25(OH)D ratio compared to term pregnancy.
印度尼西亚的新生儿死亡率仍然居高不下，早产是其中一个原因。维生素 D 水平低等营养缺乏被怀疑是早产的危险因素，但对此知之甚少。维生素 D 代谢包括 25-羟维生素 D（25(OH)D）和 1,25-二羟维生素 D（1,25(OH)D），作为无活性和活性形式，在 1α-羟化酶（CYP27B1）酶的帮助下。我们的研究旨在确定足月和早产孕妇中 25(OH)D、1,25(OH)D 和 CYP27B1 酶的差异。这是一项在印度尼西亚雅加达 Cipto Mangunkusumo 国家综合医院进行的横断面研究，时间为 2017 年 1 月至 6 月。分娩后立即采集血样，以检测母体血清和胎盘组织中的 25(OH)D 和 1,25(OH)D，以及胎盘 CYP27B1 酶。使用 SPPS 版本 20 进行统计分析以找到差异的显著性。本研究共有 60 名受试者，其中足月-早产出生组的比例为 1:1。我们发现，早产孕妇的胎盘 25(OH)D 水平显著降低（=0.001），CYP27B1/25(OH)D 比值较高。此外，还发现 CYP27B1 水平与胎盘 25(OH)D（r= -0.481，P < 0.001）和 1,25(OH)D（r= -0.365，P=0.004）水平呈显著负相关。我们的研究得出结论，与足月妊娠相比，早产孕妇的胎盘 25(OH)D 水平较低，CYP27B1/25(OH)D 比值较高。
