血清维生素 D 水平与新生儿呼吸窘迫综合征的关系。
The association of serum vitamin D level and neonatal respiratory distress syndrome.
机构信息
Department of Neonatology, Cangzhou Central Hospital, 16 Xinhua Road, Cangzhou, 061000, Hebei, China.
出版信息
Ital J Pediatr. 2023 Jan 30;49(1):16. doi: 10.1186/s13052-023-01415-w.
BACKGROUND
Neonatal respiratory distress syndrome (NRDS) is a critical disease in premature infants. Vitamin D plays an important role in promoting the development of fetal lung structure and the formation of pulmonary surfactants. This study aimed to investigate the correlation between the serum 25(OH)D level in the cord blood of premature infants and the prognosis of NRDS.
METHODS
This retrospective study recruited 82 preterm infants (gestational age 28-36 weeks) diagnosed with NRDS as the NRDS group, and 82 non-NRDS preterm infants as the control group, respectively. The diagnostic efficiency of 25(OH)D on NRDS was revealed by receiver operating characteristics curve (ROC) analysis. Enzyme linked immunosorbent assay (ELISA) was performed to evaluate the 25(OH)D level in the serum of the cord blood in preterm neonates. The NRDS risk indicators were identified by the multivariate logistic regression analysis.
RESULTS
Cord blood 25(OH)D levels were significantly lower in NRDS preterm infants than control group infants. 25(OH)D levels in cord blood can be used to predict NRDS in preterm infants. In addition, 25(OH)D levels in cord blood were positively correlated with Apgar score (1 min/5 min) and negatively correlated with oxygen support/CPAP duration in preterm infants with NRDS. 25(OH)D in cord blood <57.69 nmol/L (24 ng/ml), gestational age <31 weeks, birth weight <1.86 kg, Apgar score (1 min) <7 and Apgar score (5 min) < 8 were independent risk factors for NRDS.
CONCLUSION
25(OH)D level is an independent risk factor for NRDS in preterm infants.
背景
新生儿呼吸窘迫综合征（NRDS）是早产儿的一种危急疾病。维生素 D 在促进胎儿肺结构发育和肺表面活性物质形成方面发挥着重要作用。本研究旨在探讨早产儿脐血血清 25（OH）D 水平与 NRDS 预后的相关性。
方法
本回顾性研究纳入了 82 例（胎龄 28-36 周）被诊断为 NRDS 的早产儿为 NRDS 组，以及 82 例非 NRDS 早产儿为对照组。通过受试者工作特征曲线（ROC）分析揭示 25（OH）D 对 NRDS 的诊断效率。采用酶联免疫吸附试验（ELISA）检测早产儿脐血血清 25（OH）D 水平。采用多变量 logistic 回归分析确定 NRDS 的风险指标。
结果
NRDS 早产儿的脐血 25（OH）D 水平明显低于对照组。脐血 25（OH）D 水平可用于预测早产儿 NRDS。此外，NRDS 早产儿的脐血 25（OH）D 水平与 Apgar 评分（1 分钟/5 分钟）呈正相关，与 NRDS 早产儿的氧支持/CPAP 持续时间呈负相关。脐血 25（OH）D <57.69 nmol/L（24 ng/ml）、胎龄 <31 周、出生体重 <1.86 kg、Apgar 评分（1 分钟）<7 和 Apgar 评分（5 分钟）<8 是 NRDS 的独立危险因素。
结论
25（OH）D 水平是早产儿 NRDS 的独立危险因素。
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