一名多发性骨髓瘤患者的假性低磷血症
PSEUDOHYPOPHOSPHATEMIA IN A PATIENT WITH MULTIPLE MYELOMA.
作者信息
Wen Wu Lawrence, Choi Tak-Shun, Barbosa Monica, Chong Hyemi, Wallace Wu Ashley Garland, Soe Kyaw K
出版信息
AACE Clin Case Rep. 2020 Aug 6;6(6):e334-e337. doi: 10.4158/ACCR-2020-0389. eCollection 2020 Nov-Dec.
OBJECTIVE
To discuss the diagnosis and management of paraprotein interference in the setting of multiple myeloma (MM).
METHODS
We discuss the evaluation of hypophosphatemia in a patient with MM and present a review of the relevant literature.
RESULTS
Our patient, who had a history of MM, was found to have persistently undetectable serum phosphate which did not respond to aggressive phosphate replacement. His clinical condition was not consistent with severe phosphate depletion and hence paraprotein interference secondary to MM was suspected. Re-analyzation of samples on a different machine showed normal serum inorganic phosphate levels.
CONCLUSION
Paraprotein interference from MM causing pseudohypophosphatemia can be overlooked and lead to unnecessary treatment. Recognition of this phenomenon is important to all clinicians, especially in light of potential complications of unnecessary treatment.
目的
探讨多发性骨髓瘤（MM）患者中副蛋白干扰的诊断与处理。
方法
我们讨论了一名MM患者低磷血症的评估情况，并对相关文献进行了综述。
结果
我们的患者有MM病史，血清磷酸盐持续检测不到，积极补充磷酸盐也无反应。其临床状况与严重磷酸盐缺乏不符，因此怀疑是MM继发的副蛋白干扰。在另一台机器上重新分析样本显示血清无机磷酸盐水平正常。
结论
MM引起假性低磷血症的副蛋白干扰可能被忽视并导致不必要的治疗。认识到这一现象对所有临床医生都很重要，尤其是考虑到不必要治疗的潜在并发症。
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