Ming Yang, MD, Ph.D. Center of Gerontology and Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan, China, Phone: +86 28 8542 2321, Fax: +86 28 85542 2321, Email:
J Nutr Health Aging. 2020;24(10):1087-1093. doi: 10.1007/s12603-020-1429-x.
To assess the effectiveness of short-term exercise for treating sarcopenia in hospitalized older patients aged 80 years and over.
Prospective clinical trial.
A post-acute care unit.
Sarcopenic patients aged 80 years or over.
The participants were allocated to the intervention group (to receive a mixed exercise program with 10 sessions over two weeks) or the control group (usual care) based on the sequence of admission.
The primary outcome was the improvement in activities of daily living (ADL) estimated by the change in Barthel Index (BI) score from the baseline to the end of the 2-week intervention. The secondary outcomes were the changes in gait speed, handgrip strength, the time "UP and GO" test (TUG) score, and the Short Physical Performance Battery (SPPB) score.
We included 121 participants (intervention group: n = 62; control group: n = 59). All participants in the intervention group finished all 10 exercise sessions. After the 2-week intervention, patients in the mixed exercise group achieved a significant improvement in ADL compared with their counterparts in the control group (the adjusted mean difference of the change in BI score was 7.8 points, 95% confidence interval (CI) 4.0 to 11.8 points). The mixed exercise program significantly but slightly improved gait speed (adjusted group difference in mean change: 0.06 m/s, 95% CI 0.02 to 0.11 m/s). However, the mixed exercise program did not significantly improve the handgrip strength, SPPB score, or TUG score compared with usual care.
Very old inpatients with sarcopenia can benefit from a mixed exercise program (even as short as two weeks) by improving their ADL and gait speed. However, the long-term effects of exercise on important clinical outcomes need to be further evaluated.
评估短期运动治疗 80 岁及以上住院老年患者肌少症的疗效。
前瞻性临床试验。
康复病房。
80 岁及以上的肌少症患者。
根据入院顺序，将参与者分配到干预组（接受为期两周、共 10 次的混合运动方案）或对照组（常规护理）。
主要结局是通过从基线到 2 周干预结束时的巴氏指数（BI）评分变化来估计日常生活活动（ADL）的改善。次要结局是步态速度、握力、“起立-行走”测试（TUG）评分和简易体能状况量表（SPPB）评分的变化。
我们纳入了 121 名参与者（干预组：n=62；对照组：n=59）。干预组的所有参与者均完成了所有 10 次运动。经过 2 周的干预，混合运动组的患者在 ADL 方面的改善明显优于对照组（BI 评分变化的调整平均差异为 7.8 分，95%置信区间为 4.0 至 11.8 分）。混合运动方案显著但略有改善了步态速度（调整组间平均变化差异：0.06 m/s，95%置信区间为 0.02 至 0.11 m/s）。然而，与常规护理相比，混合运动方案并没有显著改善握力、SPPB 评分或 TUG 评分。
非常老年住院肌少症患者可以从混合运动方案（即使只有两周）中获益，改善 ADL 和步态速度。然而，运动对重要临床结局的长期影响需要进一步评估。
