Anders Vinther, Dept. Physiotherapy and Occupational therapy, Borgmester Ib Juuls Vej 29, DK-2730 Herlev, Denmark, Phone: +45-26808710 and E-mail:
J Nutr Health Aging. 2020;24(10):1120-1127. doi: 10.1007/s12603-020-1453-x.
Validation of the Danish version of the SARC-F (Strength, Assistance in walking, Rise from a chair, Climb stairs, and Falls) for hospitalized geriatric medical patients, compared against the original EWGSOP (European Working Group on Sarcopenia in Older People) and revised EWGSOP2 definition for sarcopenia. Additionally, investigation of the ability of SARC-F to individually identify low strength/function and muscle mass.
Cross-sectional analysis of data from an RCT.
Hospital, Medical Department.
122 geriatric medical patients (65.6% women) ≥ 70 years of age with mixed medical conditions.
SARC-F screening, diagnostic assessment of sarcopenia (hand-grip strength, muscle mass measured by dual-frequency bio-impedance analysis, and 4-m usual gait speed).
The prevalence of risk of sarcopenia (SARC-F ≥ 4) was 48.3%, while it was diagnosed in 65.8% and 21.7%, with EWGSOP and EWGSOP2, respectively. The sensitivity, specificity, positive predictive value, negative predictive value according to EWGSOP were 50.0 %, 53.7 %, 67.2% and 36.1%, while they were 53.8 %, 53.2 %, 24.1% and 80.6%, according to EWGSOP2 (all participants). The ability of SARC-F to predict reduced strength, function, and muscle mass was modest. There was a significant negative linear, yet weak, relationship between total SARC-F score and hand-grip strength (R2=0.033) and 4-m gait speed (R2=0.111), but not muscle mass (R2=0.004).
SARC-F does not seem to be a suitable screening tool for identifying and excluding non-sarcopenic geriatric patients. Furthermore, the SARC-F score was more strongly correlated with reduced muscle strength and physical function than with low muscle mass.
验证丹麦版 SARC-F（力量、行走辅助、从椅子上站起来、爬楼梯和跌倒）在住院老年医学患者中的有效性，与原始 EWGSOP（欧洲老年人肌少症工作组）和修订后的 EWGSOP2 肌少症定义进行比较。此外，还研究了 SARC-F 单独识别低力量/功能和肌肉质量的能力。
对随机对照试验数据进行的横断面分析。
医院，内科。
122 名年龄≥70 岁、患有多种内科疾病的老年医学患者（65.6%为女性）。
SARC-F 筛查，肌少症的诊断评估（握力、双频生物阻抗分析测量的肌肉质量和 4 米常规步行速度）。
有风险的肌少症（SARC-F≥4）的患病率为 48.3%，而根据 EWGSOP 和 EWGSOP2 的诊断率分别为 65.8%和 21.7%。根据 EWGSOP，SARC-F 的敏感性、特异性、阳性预测值和阴性预测值分别为 50.0%、53.7%、67.2%和 36.1%，而根据 EWGSOP2，它们分别为 53.8%、53.2%、24.1%和 80.6%（所有参与者）。SARC-F 预测低力量、功能和肌肉质量的能力是适度的。SARC-F 总分与握力（R2=0.033）和 4 米步行速度（R2=0.111）呈显著负线性关系，但与肌肉质量无显著相关性（R2=0.004）。
SARC-F 似乎不是一种识别和排除非肌少症老年患者的合适筛查工具。此外，SARC-F 评分与肌肉力量和身体功能降低的相关性强于与肌肉质量低的相关性。
