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股骨近端骨折的骨合成治疗:在预先存在抗凝治疗的情况下治疗时间延迟:北莱茵-威斯特法伦州外部住院患者质量保证数据的结果,基于24786例使用二次数据的病例

[Osteosynthetic treatment of proximal femoral fractures: the timing of treatment is delayed in cases of pre-existing anticoagulation : Results of the data of external inpatient quality assurance from North Rhine-Westphalia with 24,786 cases within the framework of using secondary data].

作者信息

Korbmacher J G, Schulze-Raestrup U, Nowak H, Smektala R

机构信息

Klinik für Unfallchirurgie und Orthopädie, Knappschaftskrankenhaus Bochum-Langendreer, Universitätsklinik der Ruhr Universität Bochum, In der Schornau 23-25, 44892, Bochum, Deutschland.

Qualitätssicherung NRW, Ärztekammer Westfalen-Lippe, Münster, Deutschland.

出版信息

Unfallchirurg. 2021 Aug;124(8):642-650. doi: 10.1007/s00113-020-00923-2. Epub 2020 Nov 27.

Abstract

BACKGROUND AND OBJECTIVE

Proximal femoral fractures are common in Germany with approximately 100,000 affected patients per year. The mortality could be considerably reduced by timely treatment (<24 h). The objectives of this work were to demonstrate the prevalence of anticoagulation and associated complications in osteosynthetically treated proximal femoral fractures, the impact of anticoagulation on the preoperative period and potential optimization of perioperative anticoagulation management.

MATERIAL AND METHODS

External quality control data for North Rhine-Westphalia for the years 2015-2016 were evaluated. Only cases in which a femoral fracture near the hip joint was treated osteosynthetically were analyzed. A total of 24,786 cases of femoral fractures near the hip joint were included in the study.

RESULTS

In the largest subgroup with acetylsalicylic acid (ASS) medication (n = 4005) 17% underwent delayed surgery, in the second largest group with vitamin K antagonists (VKA, n = 2157) 44.6% underwent delayed surgery and in the third largest group with direct oral anticoagulant (DOACs) medication (n = 994) 18.2% underwent delayed surgery.

CONCLUSION

The biggest potential of shortening the preoperative period can be found in the ASS and vitamin K antagonist subgroups (17% and 44.6% delayed surgery, respectively). The antagonization of the effect of VKA can be achieved within a short time by the administration of prothrombin complex (PPSB). Even when taking DOACs, the current common procedure of delayed surgical treatment must be critically questioned. A coagulation management should be established in the SOP. In addition to medical interventions (administration of antidotes), structures must be created that enable prompt care.

摘要

背景与目的

股骨近端骨折在德国较为常见,每年约有100,000名患者受影响。及时治疗(<24小时)可显著降低死亡率。本研究的目的是证明在接受骨合成治疗的股骨近端骨折中抗凝的普遍性及相关并发症,抗凝对术前阶段的影响以及围手术期抗凝管理的潜在优化。

材料与方法

评估了2015 - 2016年北莱茵 - 威斯特法伦州的外部质量控制数据。仅分析了采用骨合成方法治疗髋关节附近股骨骨折的病例。该研究共纳入24,786例髋关节附近股骨骨折病例。

结果

在使用乙酰水杨酸(ASS)药物的最大亚组(n = 4005)中,17%的患者接受了延迟手术;在使用维生素K拮抗剂(VKA,n = 2157)的第二大亚组中,44.6%的患者接受了延迟手术;在使用直接口服抗凝剂(DOACs)药物的第三大亚组(n = 994)中,18.2%的患者接受了延迟手术。

结论

缩短术前时间的最大潜力存在于ASS和维生素K拮抗剂亚组(分别为17%和44.6%的延迟手术率)。通过给予凝血酶原复合物(PPSB)可能可在短时间内实现VKA效果的拮抗。即使在服用DOACs时,目前延迟手术治疗的常见做法也必须受到严格质疑。应在标准操作规程中建立凝血管理。除了医学干预(给予解毒剂)外,还必须建立能够实现及时护理的机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0777/8370968/9f2232dc3360/113_2020_923_Fig1_HTML.jpg

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