Kovács L, Mészáros G, Pál A, Szász K
Frauenklinik der Medizinischen Universität Szeged.
Zentralbl Gynakol. 1987;109(22):1368-73.
The authors report on the results of treatment of threatening premature labour with clenbuterol. The daily dose was 40 micrograms twice and later 20 micrograms twice with good efficiency. Action of clenbuterol relating to tocolysis, metabolism and cardiovascular system has been compared with fenoterol-perlongettes. 61 pregnant patients were randomized by computer in two groups, 32 ones having clenbuterol tablets and 29 ones having fenoterol perlongettes. No electrocardiographic changes could be demonstrated with clenbuterol, but extrasystolic episodes have to be observed in two following fenoterol-perlongettes. No intravenous treatment is necessary using clenbuterol tablets. Therefore cardiac overload caused by liquid supply may be prevented, simultaneously the peril of pulmonary edema can be diminished. In our opinion tocolysis with clenbuterol tablets is a successful method of treatment of premature labor.
作者报告了用克伦特罗治疗先兆早产的结果。每日剂量为40微克，分两次服用，之后为20微克，分两次服用，效果良好。已将克伦特罗在宫缩抑制、代谢及心血管系统方面的作用与酚妥拉明长效制剂进行了比较。61例孕妇通过计算机随机分为两组，32例服用克伦特罗片，29例服用酚妥拉明长效制剂。使用克伦特罗未发现心电图变化，但服用酚妥拉明长效制剂后有两例出现早搏。服用克伦特罗片无需静脉治疗。因此可避免因补液引起的心脏负荷过重，同时可降低肺水肿的风险。我们认为，用克伦特罗片进行宫缩抑制是治疗早产的一种成功方法。
