Departamento de Bioquímica e Biologia Molecular, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, Brazil.
Can J Physiol Pharmacol. 2021 Aug;99(8):761-767. doi: 10.1139/cjpp-2020-0398. Epub 2020 Nov 27.
Studies reveal that oxidative stress is associated with adverse effects of long-term morphine treatment. The -trifluoromethyl-diphenyl diselenide (CF3) is a multi-target organoselenium compound that has antioxidant properties in different experimental models. This study aimed to investigate the CF3 effects against redox imbalance in peripheral and central tissues of mice, after single or multiple morphine doses. Swiss male mice received a single dose of morphine (5 mg/kg, s.c.) and CF3 (10 mg/kg, i.g.), or morphine was repeatedly injected (5 mg/kg, s.c.) and CF3 (10 mg/kg, i.g.) administered twice daily for 7 days. Oxidative stress was determined in the hippocampus, liver, and kidney. CF3 reversed the increase in reactive species caused by single and multiple morphine doses in the peripheral tissues. CF3 increased hepatic non-protein thiol levels and the superoxide dismutase (SOD) activity decreased by a single morphine dose. CF3 reversed the reduction in SOD activity in the kidney of mice repeatedly exposed to morphine. The study demonstrates that peripheral tissues were more susceptible than the hippocampus to oxidative stress induced by morphine in mice. The results show that CF3 modulated parameters of oxidative stress modified by single and multiple morphine administrations in peripheral and central tissues of mice.
研究表明，氧化应激与长期吗啡治疗的不良反应有关。-三氟甲基-二苯二硒（CF3）是一种多靶器官硒化合物，在不同的实验模型中具有抗氧化特性。本研究旨在探讨 CF3 对单次或多次吗啡剂量后小鼠外周和中枢组织氧化失衡的影响。雄性瑞士小鼠接受单次吗啡（5mg/kg，sc）和 CF3（10mg/kg，ig）剂量，或重复注射吗啡（5mg/kg，sc），并每日两次给予 CF3（10mg/kg，ig），共 7 天。在海马体、肝脏和肾脏中测定氧化应激。CF3 逆转了单次和多次吗啡剂量引起的外周组织中活性物质的增加。CF3 增加了肝中非蛋白巯基水平，并逆转了单次吗啡剂量引起的超氧化物歧化酶（SOD）活性降低。CF3 逆转了反复暴露于吗啡的小鼠肾脏中 SOD 活性的降低。该研究表明，与海马体相比，外周组织对吗啡诱导的氧化应激更敏感。结果表明，CF3 调节了单次和多次吗啡给药后小鼠外周和中枢组织氧化应激参数。
