Division of Neurology, Department of Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON, Canada.
Faculty of Health Sciences, Queen's University, Kingston, ON, Canada.
Mult Scler. 2021 Sep;27(10):1597-1605. doi: 10.1177/1352458520974360. Epub 2020 Nov 27.
Moderate and vigorous physical activity is associated with improved outcomes in youth with multiple sclerosis (MS). Physical fitness may also influence disease and health outcomes in this population.
To determine if there were differences in physical fitness between youth with MS and healthy controls (HC).To examine relationships between physical fitness, physical activity (PA) level, fatigue, depression and disease activity in youth with MS and HC.
Youth with MS ( = 19) and HC ( = 21) completed tests establishing cardiorespiratory-fitness (VO), endurance via 2-minute walk test, and musculoskeletal strength via grip strength (GS). Questionnaires determined fatigue, depression, and PA levels. Weekly PA level was determined by accelerometry. Tests of differences and correlational analyses were used to evaluate physical fitness.
Youth with MS had lower VO ( = 279, < 0.0001), endurance ( = 2.6, = 0.02), and higher body mass index (BMI) ( = -5.9, = 0.001) than HC. Higher VO was associated with higher moderate to vigorous PA in HC (Spearman-Rho = 0.5, = 0.03), but not in youth with MS (Spearman-Rho = 0.5, = 0.06). Lower VO and GS were associated with higher disability (Spearman-Rho = -0.6, = 0.03) and relapses in MS (Spearman-Rho = -0.52, = 0.04).
Youth with MS have lower levels of fitness, compared with HC. Higher levels of fitness were associated with lower disease activity and disability in youth with MS.
中度和剧烈的身体活动与改善多发性硬化症（MS）青年的预后相关。身体适应性也可能影响该人群的疾病和健康结果。
确定 MS 青年与健康对照（HC）之间的身体适应性是否存在差异。研究 MS 青年和 HC 之间的身体适应性、身体活动（PA）水平、疲劳、抑郁和疾病活动之间的关系。
MS 青年（n=19）和 HC（n=21）完成了心肺适能（VO）、2 分钟步行测试耐力和握力（GS）测试肌肉骨骼力量的测试。问卷确定了疲劳、抑郁和 PA 水平。每周 PA 水平通过加速度计确定。使用差异测试和相关分析来评估身体适应性。
MS 青年的 VO（ = 279， < 0.0001）、耐力（ = 2.6， = 0.02）和更高的身体质量指数（BMI）（ = -5.9， = 0.001）低于 HC。更高的 VO 与 HC 中的中等到剧烈 PA 水平较高相关（Spearman-Rho = 0.5， = 0.03），但在 MS 青年中并非如此（Spearman-Rho = 0.5， = 0.06）。较低的 VO 和 GS 与更高的残疾（Spearman-Rho = -0.6， = 0.03）和 MS 中的复发相关（Spearman-Rho = -0.52， = 0.04）。
与 HC 相比，MS 青年的身体适应性较低。更高的身体适应性与 MS 青年的疾病活动和残疾程度较低相关。
