Pang L M, Rodriguez-Martinez F, Davis W J, Mellins R B
Chest. 1977 Oct;72(4):469-73. doi: 10.1378/chest.72.4.469.
The effect of administration of terbutaline on the pulmonary and cardiovascular systems was studied in ten children with status asthmaticus. Terbutaline (0.01 to 0.04 mg/kg of body weight) was given subcutaneously in multiple doses. A significant decrease in respiratory rate and in arterial blood pressure, with no significant change in cardiac rate, was seen only after the first dose of terbutaline. There was a decrease in mean arterial carbon dioxide tension and an increase in mean arterial oxygen pressure. There was gross clinical improvement following administration of terbutaline in nine of the ten patients. One patient who failed to respond to administration of terbutaline also failed to respond to intravenously administered isoproterenol. We conclude that terbutaline is effective in the treatment of status asthmaticus, with only modest effects on the cardiovascular system.
对10名哮喘持续状态患儿研究了特布他林给药对其肺和心血管系统的影响。以多剂量皮下注射给予特布他林（0.01至0.04mg/kg体重）。仅在首次给予特布他林后，观察到呼吸频率和动脉血压显著下降，而心率无显著变化。平均动脉二氧化碳分压降低，平均动脉氧分压升高。10名患者中有9名在给予特布他林后临床症状显著改善。1名对特布他林给药无反应的患者对静脉注射异丙肾上腺素也无反应。我们得出结论，特布他林对治疗哮喘持续状态有效，对心血管系统仅有适度影响。
