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光动力疗法和光生物调节治疗下唇皮肤区域复发性疱疹:病例报告

Treatment of recurrent herpes of the lower lip skin region with photodynamic therapy and photobiomodulation: case report.

作者信息

de Araújo Sandro Roberto, Silva Diego Filipe Bezerra, Dias Isabella Jardelino, de Moura Rodrigo Queiroga, Pereira Jozinete Vieira, de Castro Gomes Daliana Queiroga

机构信息

State University of Paraíba, Paraíba, Brazil.

State University of Paraíba, Paraíba, Brazil.

出版信息

Photodiagnosis Photodyn Ther. 2021 Mar;33:102111. doi: 10.1016/j.pdpdt.2020.102111. Epub 2020 Nov 24.

Abstract

The aim of the present study is to describe a case report on the treatment of recurrent herpes using Photodynamic therapy (PDT) and Photobiomodulation as the treatments of choice. A 21-year-old white man checked in in the clinic for evaluation of vesicles arranged in the lower lip skin region. The clinical diagnosis was recurrent herpes and, for treatment, PDT was chosen, using 0.1% methylene blue as a photosensitizer and a pre-irradiation time of five minutes. The Therapy XT laser was used, with a wavelength of 660 nm, power of 100 mW, in a spot area of 0.028 cm², using 4 J energy per point, having been applied on 4 points, one in the center of the lesion and three on its laterals, so that it involved the entire extension of the lesion, totaling 16 J. After 24 hours after the application of the PDT, the patient returned for photobiomodulation with a low-power laser with a wavelength of 660 nm, power of 100 mW, using energy of 1 J per point, for 10 s, being applied on 4 points, totaling 4 J. It was possible to observe complete healing after 10 days of treatment, and the patient remains in follow-up for eight months without any recurrences.

摘要

本研究的目的是描述一例关于使用光动力疗法(PDT)和光生物调节作为首选治疗方法来治疗复发性疱疹的病例报告。一名21岁的白人男性到诊所就诊,以评估下唇皮肤区域排列的水疱。临床诊断为复发性疱疹,治疗选择了PDT,使用0.1%的亚甲蓝作为光敏剂,预照射时间为5分钟。使用Therapy XT激光,波长为660nm,功率为100mW,光斑面积为0.028cm²,每点使用4J能量,在4个点上进行照射,一个点在病变中心,三个点在病变侧面,以使整个病变范围都受到照射,总计16J。在应用PDT后24小时,患者返回进行光生物调节,使用波长为660nm、功率为100mW的低功率激光,每点使用1J能量,照射10秒,在4个点上进行照射,总计4J。治疗10天后观察到完全愈合,患者随访8个月无任何复发。

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