Al-Hallak Mai Adnan Gaizeh, Karkoutly Mawia, Hsaian Jamileh Ali, Aljoujou Abeer Ahmad
Department of Oral Medicine, Faculty of Dentistry, Damascus University, Damascus, Syrian Arab Republic.
Department of Pediatric Dentistry, Faculty of Dentistry, Damascus University, Damascus, Syrian Arab Republic.
Sci Rep. 2025 May 9;15(1):16264. doi: 10.1038/s41598-025-01331-5.
This study aimed to study the effect of combined antimicrobial photodynamic therapy (aPDT) and photobiomodulation therapy (PBMT) in the management of recurrent herpes labialis (RHL). Sixty participants were randomly assigned into three groups. Group 1 (control): 5% Acyclovir was applied as a topical cream, and a non-activating laser was applied. Group 2 (PBMT): PBMT was applied using a low-level laser therapy (LLLT) and a placebo cream. Group 3 (aPDT + PBMT): aPDT using 0.1% methylene blue with PBMT and a placebo cream. A laser diode emitting light at a wavelength of 650 nm and a power output of 100 mW was applied to each spot for 120 s. The parameters of aPDT were a wavelength of 650 nm, with power and energy density parameters set at 100 mW/ 0.1 W and 24 J/cm², respectively. Pain intensity was measured using a visual analog scale (VAS). At the baseline (t). After applying the laser (t). After 48 h (t). After utilizing the laser in the second session (t). After 7 days (t). The point of healing was the spontaneous shedding of the crust. The aPDT + PBMT group outperforms the control group in reducing pain intensity at t (p = 0.011), t (p = 0.041), and t (p = 0.005). In addition, the aPDT + PBMT group outperformed the PBMT group at t (p = 0.020). aPDT + PBMT outperforms control (p = 0.001) and PBMT (p = 0.090) groups in healing. The findings indicate that aPDT and PBMT offer a promising approach to treating RHL.
本研究旨在探讨联合抗菌光动力疗法（aPDT）和光生物调节疗法（PBMT）在复发性唇疱疹（RHL）治疗中的效果。60名参与者被随机分为三组。第1组（对照组）：外用5%阿昔洛韦乳膏，并使用非激活激光。第2组（PBMT组）：采用低强度激光疗法（LLLT）和安慰剂乳膏进行PBMT。第3组（aPDT + PBMT组）：使用0.1%亚甲蓝进行aPDT，并联合PBMT和安慰剂乳膏。将波长为650 nm、输出功率为100 mW的激光二极管照射每个部位120秒。aPDT的参数为波长650 nm，功率和能量密度参数分别设置为100 mW/0.1 W和24 J/cm²。使用视觉模拟量表（VAS）测量疼痛强度。在基线时（t）。应用激光后（t）。48小时后（t）。在第二次治疗中应用激光后（t）。7天后（t）。愈合点为痂皮自然脱落。aPDT + PBMT组在t时（p = 0.011）、t时（p = 0.041）和t时（p = 0.005）在减轻疼痛强度方面优于对照组。此外，aPDT + PBMT组在t时优于PBMT组（p = 0.020）。在愈合方面，aPDT + PBMT优于对照组（p = 0.001）和PBMT组（p = 0.090）。研究结果表明，aPDT和PBMT为治疗RHL提供了一种有前景的方法。
