Medical Undergraduate Program, Faculty of Medicine, University of British Columbia, BC, Canada.
Department of Pathology, Vancouver General Hospital and University of British Columbia, 1215 - 910 West 10th Avenue, Vancouver BC, Canada; Genetic Pathology Evaluation Center (GPEC), BC, Canada.
Semin Diagn Pathol. 2021 Jan;38(1):37-49. doi: 10.1053/j.semdp.2020.09.004. Epub 2020 Sep 6.
Squamous cell carcinoma of the vulva is a rare gynecologic cancer that is associated with significant patient morbidity and mortality, particularly for recurrent disease. This review summarizes the evidence and continued challenges, regarding the traditional clinicopathologic factors used to prognosticate vulvar squamous cell carcinoma. Articles published within the last 10 years (2010-2020) were identified. Relevant articles concerning the following fifteen prognostic factors were reviewed: HPV/p16 status, vulvar intraepithelial neoplasia, patient age, tumor stage, tumor grade, tumor size, depth of invasion, stromal changes, histologic patterns of invasion, lymphovascular space invasion (LVSI), perineural invasion, lymph node metastases, tumour focality, margin status and lichen sclerosus (LS). The relationship between each prognostic factor and progression-free survival (PFS) and overall survival (OS), including hazard ratios, 95% confidence intervals and p-values, were extracted.
外阴鳞状细胞癌是一种罕见的妇科癌症，与患者发病率和死亡率显著相关，尤其是复发性疾病。本综述总结了用于预测外阴鳞状细胞癌的传统临床病理因素的证据和持续存在的挑战。检索了过去 10 年（2010-2020 年）发表的文章。回顾了与以下十五个预后因素相关的相关文章：HPV/p16 状态、外阴上皮内瘤变、患者年龄、肿瘤分期、肿瘤分级、肿瘤大小、浸润深度、间质改变、浸润组织学模式、血管淋巴管间隙浸润（LVSI）、神经周围浸润、淋巴结转移、肿瘤局灶性、切缘状态和硬化性苔藓（LS）。提取了每个预后因素与无进展生存率（PFS）和总生存率（OS）的关系，包括风险比、95%置信区间和 p 值。
