, Solagna, Italy.
Doctors With Africa CUAMM, Padua, Italy.
Sci Rep. 2020 Nov 27;10(1):20800. doi: 10.1038/s41598-020-77778-5.
Both neonatal hypothermia and hyperthermia represent important risk factors for neonatal mortality, but information on mortality risk across a full range of neonatal temperatures is lacking in low-resource settings. We evaluated the association between neonatal mortality and a full range of admission temperatures in a low-resource setting. This retrospective observational study was conducted at Beira Central Hospital, Mozambique. The relationship between admission temperature and mortality was evaluated using multivariable analyses with temperature modeled as non-linear term. Among 2098 neonates admitted to the Special Care Unit between January-December 2017, admission temperature was available in 1344 neonates (64%) who were included in the analysis. A non-linear association between mortality rate and temperature was identified. Mortality rate decreased from 84% at 32 °C to 64% at 34.6 °C (- 8% per °C), to 41% at 36 °C (- 16% per °C), to 26% to 36.6 °C (- 25% per °C) and to 22% at 38.3 °C (- 2% per °C), then increased to 40% at 41 °C (+ 7% per °C). Mortality rate was estimated to be at minimum at admission temperature of 37.5 °C. In conclusions, the non-linear relationship highlighted different mortality risks across a full range of neonatal temperatures in a low-resource setting. Admission temperature was not recorded in one third of neonates.
新生儿低体温和高体温均是新生儿死亡的重要危险因素，但在资源匮乏的环境中，关于新生儿全范围体温与死亡率之间关系的信息尚不清楚。我们评估了资源匮乏环境中新生儿死亡率与全范围入院体温之间的关系。这是一项在莫桑比克贝拉中央医院进行的回顾性观察性研究。使用多变量分析评估入院体温与死亡率之间的关系，将体温作为非线性项进行建模。在 2017 年 1 月至 12 月期间入住特护病房的 2098 名新生儿中，有 1344 名（64%）新生儿的入院体温可用于分析。确定了死亡率与温度之间的非线性关系。死亡率从 32°C 时的 84%下降到 34.6°C 时的 64%（每°C 下降 8%），到 36°C 时的 41%（每°C 下降 16%），到 36.6°C 时的 26%至 26%（每°C 下降 25%）和 38.3°C 时的 22%（每°C 下降 2%），然后增加到 41°C 时的 40%（每°C 增加 7%）。估计入院体温为 37.5°C 时死亡率最低。总之，该非线性关系突出了资源匮乏环境中新生儿全范围体温的不同死亡率风险。三分之一的新生儿入院体温未被记录。
