Department of Otolaryngology-Head and Neck Surgery, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Am J Clin Nutr. 2021 Feb 2;113(2):456-466. doi: 10.1093/ajcn/nqaa310.
The elderly are at increased risk of both hearing loss (HL) and osteoporosis. Bone mineral density (BMD) has been putatively linked to HL. However, the roles of serum calcium concentrations and vitamin D status have yet to be elucidated.
The purpose of this study was to examine the relation between vitamin D status, parathyroid hormone (PTH), total calcium, BMD, and HL in a nationally representative sample of elderly adults.
Using the NHANES (2005-2010), audiometry and BMD data of 1123 participants aged ≥70 y were analyzed in a cross-sectional manner. HL was defined as pure tone averages >25 dB HL at 500, 1000, and 2000 Hz (low frequency); 500, 1000, 2000, and 4000 Hz (speech frequency); and 3000, 4000, 6000, and 8000 Hz (high frequency) in either ear. Multivariable logistic regression was used to examine the relation between HL and total 25-hydroxyvitamin D [25(OH)D], PTH, total calcium, and BMD, adjusting for covariates.
In multivariable analyses, total 25(OH)D < 20 ng/mL was found to be associated with greater odds of low-frequency HL (OR: 2.02; 95% CI: 1.28, 3.19) and speech-frequency HL (OR: 1.96; 95% CI: 1.12, 3.44). A 1-unit decrease in femoral neck BMD (OR: 4.55; 95% CI: 1.28, 16.67) and a 1-unit decrease in total spine BMD (OR: 6.25; 95% CI: 1.33, 33.33) were found to be associated with greater odds of low-frequency HL. Serum PTH and total calcium were not found to be associated with HL.
In the elderly, low vitamin D status was associated with low-frequency and speech-frequency HL. Low vitamin D status may be a potential risk factor for age-related HL.
老年人听力损失（HL）和骨质疏松症的风险均增加。骨矿物质密度（BMD）与 HL 有一定的关联。然而，血清钙浓度和维生素 D 状况的作用尚未阐明。
本研究旨在检查维生素 D 状况、甲状旁腺激素（PTH）、总钙、BMD 与老年人中 HL 的关系。
使用 NHANES（2005-2010 年），对 1123 名年龄≥70 岁的参与者的听力和 BMD 数据进行横断面分析。HL 定义为双耳任何一耳的 500、1000 和 2000 Hz（低频）；500、1000、2000 和 4000 Hz（言语频率）；以及 3000、4000、6000 和 8000 Hz（高频）处纯音平均值>25 dB HL。多变量逻辑回归用于检查 HL 与总 25-羟维生素 D [25(OH)D]、PTH、总钙和 BMD 之间的关系，同时调整协变量。
在多变量分析中，发现总 25(OH)D<20ng/mL 与低频 HL（OR：2.02；95%CI：1.28，3.19）和言语频率 HL（OR：1.96；95%CI：1.12，3.44）的几率增加有关。股骨颈 BMD 降低 1 个单位（OR：4.55；95%CI：1.28，16.67）和总脊柱 BMD 降低 1 个单位（OR：6.25；95%CI：1.33，33.33）与低频 HL 的几率增加有关。血清 PTH 和总钙与 HL 无关。
在老年人中，低维生素 D 状态与低频和言语频率 HL 有关。低维生素 D 状态可能是与年龄相关 HL 的潜在危险因素。
