Department of Microbiology, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India.
BRULAC-DRC, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India.
Asian Pac J Cancer Prev. 2020 Nov 1;21(11):3435-3439. doi: 10.31557/APJCP.2020.21.11.3435.
Brain abundant membrane attached signal protein 1 (BASP1) was originally identified as a membrane and cytoplasmic protein. Recent studies have shown that BASP1 highly expressed in cancer and promoted the proliferation of cancer. However, the role of BASP1 in head and neck squamous cell carcinoma (HNSCC) is largely unknown. Here, we performed a systematic data analysis to examine whether BASP1 can function as prognostic marker in HNSCC.
In this study, we used Oncomine, and UALCAN, databases to analyze the expression of BASP1 in HNSCC. We used Kaplan-Meier plotter to evaluate the effect of BASP1 on clinical prognosis. In addition, we also analyzed genetic alterations, interaction network, and functional enrichment of BASP1.
BASP1 mRNA expression level was remarkably increased in HNSCC than in normal tissues (P=1.624e-12). Moreover, high BASP1 expression was significantly related to poor survival (p=0.00056) in HNSCC patients. In addition, BASP1 gene amplified in 5% of HNSCC patients which contributes to the overexpression of BASP1.
These findings suggest that BASP1 was frequently amplified which contributes to the overexpression of BASP1, thereby promoting HNSCC progression. Thus, these results indicate that BASP1 might serve as a biomarker to predict the progression and prognosis of HNSCC patients.
脑丰富膜附着信号蛋白 1（BASP1）最初被鉴定为一种膜和细胞质蛋白。最近的研究表明，BASP1 在癌症中高表达，并促进了癌症的增殖。然而，BASP1 在头颈部鳞状细胞癌（HNSCC）中的作用在很大程度上是未知的。在这里，我们进行了系统的数据分析，以检查 BASP1 是否可以作为 HNSCC 的预后标志物。
在这项研究中，我们使用 Oncomine 和 UALCAN 数据库来分析 BASP1 在 HNSCC 中的表达。我们使用 Kaplan-Meier plotter 来评估 BASP1 对临床预后的影响。此外，我们还分析了 BASP1 的遗传改变、相互作用网络和功能富集。
与正常组织相比，BASP1 mRNA 表达水平在 HNSCC 中显著增加（P=1.624e-12）。此外，BASP1 高表达与 HNSCC 患者的不良生存显著相关（p=0.00056）。此外，BASP1 基因在 5%的 HNSCC 患者中扩增，导致 BASP1 的过表达。
这些发现表明，BASP1 经常扩增，导致 BASP1 的过表达，从而促进 HNSCC 的进展。因此，这些结果表明 BASP1 可能作为预测 HNSCC 患者进展和预后的标志物。
