芝麻酚及其衍生物的制备和抗氧化活性。

Preparations and antioxidant activities of sesamol and it's derivatives.

机构信息

College of Chemistry and Chemical Engineering, Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, China; Active Carbohydrate Research Institute, Chongqing Key Laboratory of Inorganic Functional Materials, College of Chemistry, Chongqing Normal University, Chongqing 401331, China.

College of Chemistry and Chemical Engineering, Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, China.

出版信息

Bioorg Med Chem Lett. 2021 Jan 1;31:127716. doi: 10.1016/j.bmcl.2020.127716. Epub 2020 Nov 26.

DOI:10.1016/j.bmcl.2020.127716

PMID:33249134

Abstract

Antioxidants is a kind of substances that can effectively inhibit the oxidation reaction of free radicals. There are many chemical components with antioxidant activity in natural products. Sesamol is one of the natural products with antioxidant activity, and it is often used as an antioxidant in food, medicine and other fields. In the present study, sesame was used as the extraction raw material for the extraction and separated of sesamol with antioxidant activity. On this basis, a total 10 of sesamol derivatives were synthesized by two steps reaction with sesamol as starting material. The antioxidant activity of these sesamol derivatives were tested, and the test results showed that these sesamol derivatives had a good antioxidant activity, among them, compound 4d had the best antioxidant activity. Sesamol derivatives can be used as an antioxidant in food, medicine and other fields and it needs a further study.

摘要

抗氧化剂是一种能有效抑制自由基氧化反应的物质。天然产物中有许多具有抗氧化活性的化学成分。芝麻酚是具有抗氧化活性的天然产物之一，常作为食品、医药等领域的抗氧化剂。本研究以芝麻为提取原料，对具有抗氧化活性的芝麻酚进行提取分离。在此基础上，以芝麻酚为起始原料，经两步反应合成了 10 种芝麻酚衍生物。对这些芝麻酚衍生物的抗氧化活性进行了测试，结果表明，这些芝麻酚衍生物具有良好的抗氧化活性，其中化合物 4d 的抗氧化活性最好。芝麻酚衍生物可作为食品、医药等领域的抗氧化剂，有待进一步研究。