Jung Sra, Kim Ji-Hye, Kang Na-Ok, Sung Gihye, Ko Young-Gun, Bang Minji, Park Chun Il, Lee Sang-Hyuk
Department of Psychiatry, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea.
CHA University School of Medicine, Seongnam, Republic of Korea.
Psychiatry Res Neuroimaging. 2021 Jan 30;307:111226. doi: 10.1016/j.pscychresns.2020.111226. Epub 2020 Nov 23.
Impaired social cue perception such as emotional recognition is a prominent feature in patients with schizophrenia, adversely affecting psychosocial outcomes and worsening clinical manifestations of the disease. However, few structural neuroimaging studies have investigated both facial emotion recognition and emotion intensity recognition in schizophrenia. Ninety patients with schizophrenia spectrum psychosis and fifty healthy controls underwent structural magnetic resonance imaging. The gray matter volumes of emotion recognition areas such as the bilateral caudal anterior cingulate cortex, rostral anterior cingulate cortex, fusiform gyrus, insula, amygdala, and hippocampus, were compared between patients and controls. Emotional recognition levels and symptom severities were examined. Group analysis showed that the gray matter volumes of the patients were significantly smaller in left hippocampus and fusiform gyrus compared with healthy controls. A correlation analysis revealed that larger left fusiform gyrus volume was associated with better facial emotion recognition and emotional intensity recognition in patients with schizophrenia spectrum psychosis. Additionally, left fusiform gyrus volumes showed a significant negative correlation with the negative symptom scores at baseline. These findings suggest that gray matter abnormalities in the left fusiform gyrus are associated with impaired social emotion recognition and severity of negative symptoms at baseline in patients with schizophrenia spectrum psychosis.
社会线索感知受损，如情绪识别，是精神分裂症患者的一个突出特征，对心理社会结局产生不利影响，并使该疾病的临床表现恶化。然而，很少有结构神经影像学研究同时调查精神分裂症患者的面部情绪识别和情绪强度识别。90名精神分裂症谱系精神病患者和50名健康对照者接受了结构磁共振成像检查。比较了患者和对照者双侧尾侧前扣带回皮质、喙侧前扣带回皮质、梭状回、脑岛、杏仁核和海马体等情绪识别区域的灰质体积。检查了情绪识别水平和症状严重程度。组间分析显示，与健康对照者相比，患者左侧海马体和梭状回的灰质体积显著较小。相关性分析显示，左侧梭状回体积较大与精神分裂症谱系精神病患者更好的面部情绪识别和情绪强度识别相关。此外，左侧梭状回体积与基线时的阴性症状评分呈显著负相关。这些发现表明，左侧梭状回的灰质异常与精神分裂症谱系精神病患者的社会情绪识别受损和基线时阴性症状的严重程度相关。
