Toubi Elias, Vadasz Zehava
Division of Allergy and Clinical Immunology, Bnai Zion Medical Center, affiliated with Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Isr Med Assoc J. 2020 Nov;11(22):717-719.
Innate and adaptive immune response dysregulations are equally involved in the induction of autoimmunity. Toll-like receptors play a leading role in the activation of innate immune cells, thus priming auto-reactive T cells. Th17 cells and related cytokines are widely involved in many immune-mediated diseases such as rheumatoid arthritis. Thus, the recent introduction of anti-IL-17 therapies should be further evaluated. Janus kinase inhibitors and Fc receptor-targeting drugs are some of the new therapeutic strategies that are being implemented when old classical therapies lack sufficient beneficial outcomes.
先天性和适应性免疫反应失调同样参与自身免疫的诱导。Toll样受体在先天性免疫细胞的激活中起主导作用，从而启动自身反应性T细胞。Th17细胞和相关细胞因子广泛参与许多免疫介导的疾病，如类风湿性关节炎。因此，最近引入的抗IL-17疗法应进一步评估。当传统经典疗法缺乏足够的有益效果时，Janus激酶抑制剂和靶向Fc受体的药物是正在实施的一些新治疗策略。
