Kuna Matea, Štefanović Mario, Ladika Davidović Blaženka, Mandušić Nikolina, Birkić Belanović Ines, Lugović-Mihić Liborija
Department of Dermatovenereology, University Hospital Center "Sestre Milosrdnice", Vinogradska 29, 10000 Zagreb, Croatia.
Department of Clinical Chemistry, University Hospital Center "Sestre Milosrdnice", Vinogradska 29, 10000 Zagreb, Croatia.
Biomedicines. 2023 Aug 9;11(8):2232. doi: 10.3390/biomedicines11082232.
(1) Background: To assess the relationship between serum interleukin-6 (IL-6), erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) values and disease severity in patients with chronic spontaneous urticaria (CSU) and to examine which of these serum biomarkers better indicates disease severity. (2) Methods: Our pilot study included 20 patients with CSU who filled out questionnaires concerning disease severity and quality of life (the Urticaria Activity Score summed over 7 days [UAS7], the once-daily Urticaria Activity Score [UAS], the Urticaria Control Test [UCT], and the Dermatology Life Quality Index [DLQI]). Blood samples were taken to measure IL-6, ESR and CRP. (3) Results: ESR significantly correlated with the UAS7 (linear and moderate correlation; r = 0.496; = 0.026), while CRP did not correlate with disease severity. IL-6 correlated with the once-daily UAS (r = 0.472; = 0.036) and DLQI (r = 0.504; = 0.023) (linear and moderate correlation) but not the UAS7 or UCT. (4) Conclusions: IL-6 was a better indicator of the once-daily UAS and DLQI, while ESR was a better indicator of the UAS7 (there was no correlation between IL-6, CRP and ESR parameters). Although our results are promising, this study should be conducted with a larger number of CSU patients.
(1) 背景：评估慢性自发性荨麻疹（CSU）患者血清白细胞介素-6（IL-6）、红细胞沉降率（ESR）和C反应蛋白（CRP）值与疾病严重程度之间的关系，并检查这些血清生物标志物中哪一种能更好地指示疾病严重程度。(2) 方法：我们的初步研究纳入了20例CSU患者，他们填写了关于疾病严重程度和生活质量的问卷（7天荨麻疹活动评分总和[UAS7]、每日一次荨麻疹活动评分[UAS]、荨麻疹控制试验[UCT]和皮肤病生活质量指数[DLQI]）。采集血样以测量IL-6、ESR和CRP。(3) 结果：ESR与UAS7显著相关（线性中度相关；r = 0.496；P = 0.026），而CRP与疾病严重程度无关。IL-6与每日一次的UAS（r = 0.472；P = 0.036）和DLQI（r = 0.504；P = 0.023）相关（线性中度相关），但与UAS7或UCT无关。(4) 结论：IL-6是每日一次UAS和DLQI的更好指标，而ESR是UAS7的更好指标（IL-6、CRP和ESR参数之间无相关性）。尽管我们的结果很有前景，但本研究应以更多的CSU患者进行。
