Mest H J, Schneider S, Riedel A
Department of Pharmacology and Toxicology, Martin Luther University, Halle, GDR.
Biomed Biochim Acta. 1987;46(8-9):S534-8.
The balance between the eicosanoids seems to be involved in the biochemical regulation of cardiac rhythm. Under several pathophysiological conditions thromboxane (TX) could be an important factor for the genesis of cardiac arrhythmias. Shifting the balance between the arrhythmogenic TX and the antiarrhythmic prostacyclin (PGI2) in favour of PGI2 by substances influencing the arachidonic acid cascade might by useful for the treatment of arrhythmias. PAF induced toxic arrhythmogenicity seems to be mediated by TX. Therefore the suppression of TX influence can antagonize these arrhythmias, too.
类二十烷酸之间的平衡似乎参与了心脏节律的生化调节。在几种病理生理条件下，血栓素（TX）可能是心律失常发生的一个重要因素。通过影响花生四烯酸级联反应的物质，使致心律失常的TX和抗心律失常的前列环素（PGI2）之间的平衡向有利于PGI2的方向转变，可能对心律失常的治疗有用。血小板活化因子（PAF）诱导的毒性致心律失常作用似乎是由TX介导的。因此，抑制TX的影响也可以对抗这些心律失常。
