Riedel A, Mest H J
Prostaglandins Leukot Med. 1987 Jun;28(1):103-9. doi: 10.1016/0262-1746(87)90051-5.
Platelet-activating factor (PAF), 10(-11) mol decreased the threshold of ouabain induced arrhythmia in guinea-pigs. The thresholds inducing premature ventricular beats and ventricular flutter were statistically significantly decreased by 27.4% and 15.6%, respectively. BM 13.177 (30 mg/kg), a thromboxane receptor antagonizing substance, and esculetin (1.2 mg/kg), a lipoxygenase inhibitor, abolished this arrhythmogenic effect of PAF. Acetylsalicylic acid (10 mg/kg) showed only a tendency to inhibit the PAF effect. These results suggest that PAF could play a role in cardiac arrhythmias under special conditions and it supports the hypothesis that PAF action is mediated by the release of leukotrienes and thromboxane.
血小板活化因子（PAF），10⁻¹¹摩尔可降低豚鼠哇巴因诱发心律失常的阈值。诱发室性早搏和室性扑动的阈值分别在统计学上显著降低了27.4%和15.6%。血栓素受体拮抗物质BM 13.177（30毫克/千克）和脂氧合酶抑制剂七叶亭（1.2毫克/千克）消除了PAF的这种致心律失常作用。乙酰水杨酸（10毫克/千克）仅表现出抑制PAF作用的趋势。这些结果表明，PAF可能在特殊情况下的心律失常中起作用，并且支持PAF作用是由白三烯和血栓素的释放介导的这一假说。
