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病毒在肝脏中的传播：机制、共性及未解决的问题。

Virus spread in the liver: mechanisms, commonalities, and unanswered questions.

作者信息

Tallan Alexi, Feng Zongdi

机构信息

Center for Vaccines & Immunity, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA.

Department of Pediatrics, Ohio State University College of Medicine, Columbus OH 43210, USA.

出版信息

Future Virol. 2020 Oct;15(10):707-715. doi: 10.2217/fvl-2020-0158. Epub 2020 Oct 27.

DOI:10.2217/fvl-2020-0158
PMID:33250929
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7675010/
Abstract

The liver is home to five known human hepatitis viruses (hepatitis A virus-hepatitis E virus). Despite being phylogenetically unrelated, these viruses replicate and spread in the liver without causing apparent cytopathic effects, and all have evolved strategies to counteract antibody-mediated inhibition of virus spread. In this review, we discuss the current understanding regarding the spread mechanisms for these viruses with an attempt to extract common principles and identify key questions for future studies.

摘要

肝脏是五种已知人类肝炎病毒（甲型肝炎病毒至戊型肝炎病毒）的宿主。尽管这些病毒在系统发育上没有亲缘关系，但它们在肝脏中复制和传播，却不会引起明显的细胞病变效应，并且都进化出了对抗抗体介导的病毒传播抑制作用的策略。在这篇综述中，我们讨论了目前对这些病毒传播机制的理解，试图提炼出共同原则，并确定未来研究的关键问题。

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本文引用的文献

1
Progress towards elimination goals for viral hepatitis.
Nat Rev Gastroenterol Hepatol. 2020 Sep;17(9):533-542. doi: 10.1038/s41575-020-0332-6. Epub 2020 Jul 23.
2
Current knowledge on Hepatitis Delta Virus replication.
Antiviral Res. 2020 Jul;179:104812. doi: 10.1016/j.antiviral.2020.104812. Epub 2020 Apr 29.
3
Retinoic Acid and Lymphotoxin Signaling Promote Differentiation of Human Intestinal M Cells.
Gastroenterology. 2020 Jul;159(1):214-226.e1. doi: 10.1053/j.gastro.2020.03.053. Epub 2020 Apr 1.
4
Hepatitis B virus entry into HepG2-NTCP cells requires clathrin-mediated endocytosis.
Cell Microbiol. 2020 Aug;22(8):e13205. doi: 10.1111/cmi.13205. Epub 2020 Apr 1.
5
Hepatitis A virus structural protein pX interacts with ALIX and promotes the secretion of virions and foreign proteins through exosome-like vesicles.
J Extracell Vesicles. 2020 Jan 22;9(1):1716513. doi: 10.1080/20013078.2020.1716513. eCollection 2020.
6
Viral Hepatitis: Etiology, Epidemiology, Transmission, Diagnostics, Treatment, and Prevention.
Infect Dis Clin North Am. 2019 Dec;33(4):1045-1062. doi: 10.1016/j.idc.2019.08.004.
7
Hepatitis E Virus Entry.
Viruses. 2019 Sep 20;11(10):883. doi: 10.3390/v11100883.
8
Hepatitis C Virus Entry: Protein Interactions and Fusion Determinants Governing Productive Hepatocyte Invasion.
Cold Spring Harb Perspect Med. 2020 Feb 3;10(2):a036830. doi: 10.1101/cshperspect.a036830.
9
Revisiting Hepatitis B Virus: Challenges of Curative Therapies.
J Virol. 2019 Sep 30;93(20). doi: 10.1128/JVI.01032-19. Print 2019 Oct 15.
10
Enveloped viruses distinct from HBV induce dissemination of hepatitis D virus in vivo.
Nat Commun. 2019 May 8;10(1):2098. doi: 10.1038/s41467-019-10117-z.

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