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电离室在超高脉冲剂量电子束中的离子收集效率。

Ion collection efficiency of ionization chambers in ultra-high dose-per-pulse electron beams.

机构信息

PTW-Freiburg, Freiburg, 79115, Germany.

University Clinic for Medical Radiation Physics, Medical Campus Pius Hospital, Carl von Ossietzky University, Oldenburg, 26121, Germany.

出版信息

Med Phys. 2021 Feb;48(2):819-830. doi: 10.1002/mp.14620. Epub 2021 Jan 3.

Abstract

PURPOSE

The ion collection efficiency of vented ionization chambers has been investigated in an ultra-high dose-per-pulse (DPP) electron beam. The role of the chamber design and the electric field strength in the sensitive air volume have been evaluated.

METHODS

An advanced Markus chamber and three specially designed parallel plate air-filled ionization chambers (EWC: End Window Chamber) with varying electrode distance of 0.5, 1, and 2 mm have been investigated. Their ion collection efficiencies were determined experimentally using two methods: extrapolation of Jaffé plots and comparison against a DPP-independent reference detector. The latter was achieved by calibrating a current transformer against alanine dosimeters. All measurements were performed in a 24 MeV electron beam with DPP values between 0.01 and 3 Gy. Additionally, the numerical approach introduced by Gotz et al. was implemented taking into account space charge effects at these ultra-high DPPs. The method has been extended to obtain time-resolved and position-dependent electric field distortions within the air cavity.

RESULTS

The ion collection efficiency of the investigated ionization chambers drops significantly in the ultra-high DPP range. The extent of this drop is dependent on the electrode distance, the applied chamber voltage and thus the field strength in the sensitive air volume. For the Advanced Markus chamber, a good agreement between the experimental, numerical and the results of Petersson et al. could be shown. Using the three EWCs with different electrode spacing, an improvement of the ion collection efficiency and a reduction of the polarity effect with decreasing electrode distance could be demonstrated. Furthermore, the results revealed that the determination of the ion collection efficiency from the Jaffé plots and therefore also from two-voltage method typically underestimate the ion collection efficiency in the region of high dose-per-pulse (3 to 130 mGy) and overestimate the ion collection efficiency at ultra-high dose-per-pulse (>1 Gy per pulse).

CONCLUSIONS

In this work, the ion collection efficiency determined with different methods and ionization chambers have been compared and discussed. As expected, an increase of the electric field in the ionization chamber, either by applying a higher bias voltage or a reduction of the electrode distance, improves the ion collection efficiency and also reduces the polarity effect. For the Advanced Markus chamber, the experimental results obtained by comparison against a reference agree well with the numerical solution. Based on these results, it seems possible to keep the recombination loss less than or equal to 5% up to a dose-per-pulse of 3 Gy with an appropriately designed ionization chamber, which corresponds to the level accepted in conventional radiotherapy dosimetry protocols.

摘要

目的

研究了超高脉冲剂量(DPP)电子束中通风电离室的离子收集效率。评估了腔室设计和敏感空气体积内电场强度的作用。

方法

使用两种方法对先进的 Markus 室和三个具有不同电极距离(0.5、1 和 2mm)的特殊设计的平行板空气填充电离室(EWC:端窗室)进行了研究:Jaffé 图的外推和与 DPP 无关的参考探测器进行比较。后者通过将电流互感器校准到丙氨酸剂量计来实现。所有测量均在 24MeV 电子束中进行,DPP 值在 0.01 到 3Gy 之间。此外,还采用 Gotz 等人提出的数值方法,考虑了超高 DPP 下的空间电荷效应。该方法已扩展到获得空气腔内随时间和位置变化的电场畸变。

结果

研究中的电离室的离子收集效率在超高 DPP 范围内显著下降。下降的程度取决于电极距离、施加的腔室电压以及敏感空气体积内的场强。对于先进的 Markus 室,可以很好地显示实验、数值和 Petersson 等人的结果之间的一致性。使用具有不同电极间距的三个 EWC,可以证明离子收集效率的提高和随着电极距离的减小极性效应的降低。此外,结果表明,从 Jaffé 图确定离子收集效率,因此也从双电压法确定,在高剂量脉冲(3 到 130mGy)区域会低估离子收集效率,而在超高剂量脉冲(每脉冲超过 1Gy)时会高估离子收集效率。

结论

在这项工作中,比较和讨论了使用不同方法和电离室确定的离子收集效率。正如预期的那样,通过施加更高的偏置电压或减小电极距离来增加电离室中的电场,会提高离子收集效率并降低极性效应。对于先进的 Markus 室,通过与参考比较获得的实验结果与数值解吻合得很好。基于这些结果,似乎有可能将复合损失保持在 5%以内,直到剂量脉冲达到 3Gy,使用适当设计的电离室,这与传统放射治疗剂量学协议中接受的水平相当。

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