Division of Global HIV and TB, Centers for Disease Control and Prevention, Atlanta, GA.
Division of Global HIV and TB, Centers for Disease Control and Prevention, Maputo, Mozambique.
J Acquir Immune Defic Syndr. 2021 Apr 1;86(4):e97-e105. doi: 10.1097/QAI.0000000000002583.
Early antiretroviral therapy (ART) is necessary for HIV epidemic control and depends on early diagnosis and successful linkage to care. Since 2014, annual household-based HIV testing and counseling and linkage services have been provided through the Chókwè Health and Demographic Surveillance System for residents testing HIV positive in this high HIV-burden district.
District-wide Test and Start [T&S, ART for all people living with HIV (PLHIV)] began in August 2016, supported by systematic interventions to improve linkage to care and treatment. Annual rounds (R) of random household surveys were conducted to assess trends in population prevalence of ART use and viral load suppression (<1000 viral RNA copies/mL).
Between R1 (April 2014-April 2015) and R5 (April 2018-Mar 2019), 46,090 (67.2%) of 68,620 residents aged 15-59 years were tested for HIV at home at least once, and 3711 were newly diagnosed with HIV and provided linkage services. Population prevalence of current ART use among PLHIV increased from 65.0% to 87.5% between R1 and R5. ART population prevalence was lowest among men aged 25-34 years (67.8%) and women aged 15-24 (78.0%), and highest among women aged 35-44 years (93.6%) and 45-59 years (93.7%) in R5. Viral load suppression prevalence increased among all PLHIV aged 15-59 years from 52.0% in R1 to 78.3% in R5.
Between 2014 and 2019, Chókwè Health and Demographic Surveillance System residents surpassed the UNAIDS targets of ≥81% of PLHIV on ART and ≥73% virally suppressed. This achievement supports the combination of efforts from household-based HIV testing and counseling, support for linkage to care and treatment, and continued investments in T&S implementation.
早期抗逆转录病毒治疗(ART)对于 HIV 疫情控制至关重要,这依赖于早期诊断和成功链接到护理。自 2014 年以来,通过 Chókwè 健康和人口监测系统,为在这个 HIV 负担沉重的地区检测到 HIV 阳性的居民提供了年度基于家庭的 HIV 检测和咨询以及链接服务。
全区测试和启动[测试和启动,所有 HIV 感染者(PLHIV)的 ART]于 2016 年 8 月开始,得到了改善链接到护理和治疗的系统干预的支持。每年进行一轮(R)随机家庭调查,以评估人口中接受 ART 治疗和病毒载量抑制(<1000 个病毒 RNA 拷贝/ml)的趋势。
在 R1(2014 年 4 月至 2015 年 4 月)和 R5(2018 年 4 月至 2019 年 3 月)之间,68620 名 15-59 岁居民中有 46090 人(67.2%)在家中至少接受过一次 HIV 检测,3711 人被新诊断为 HIV 并提供了链接服务。PLHIV 中当前接受 ART 治疗的人口比例从 R1 时的 65.0%增加到 R5 时的 87.5%。在 R5 时,25-34 岁男性(67.8%)和 15-24 岁女性(78.0%)中 ART 人群比例最低,而 35-44 岁女性(93.6%)和 45-59 岁女性(93.7%)中 ART 人群比例最高。在所有 15-59 岁的 PLHIV 中,病毒载量抑制率从 R1 时的 52.0%增加到 R5 时的 78.3%。
在 2014 年至 2019 年期间,Chókwè 健康和人口监测系统的居民超过了 UNAIDS 的目标,即接受 ART 的 PLHIV 中≥81%和病毒载量抑制率≥73%。这一成就支持了家庭为基础的 HIV 检测和咨询、支持链接到护理和治疗以及对 T&S 实施的持续投资的结合。