甲基取代的N-(5-嘧啶基)苯磺酰胺衍生物的抗真菌作用
Antimycotic action of methyl substituted N-(5-pyrimidinyl)benzenesulfonamide derivatives.
作者信息
Pecorari P, Vampa G, Albasini A, Provvisionato A
机构信息
Dipartimento di Scienze Farmaceutiche, Università di Modena, Italy.
出版信息
Farmaco Sci. 1987 Oct;42(10):747-53.
PMID:3325305
Abstract
Some series of N-(5-pyrimidinyl)benzenesulfonamide variously methylated at the ring and/or sulfonamidic nitrogens and substituted at the benzene with NO2 or NH2 were synthesized and studied spectrometrically (N.M.R). When tested on several strains of Candida albicans and Candida tropicalis, some of the compounds exhibited very slight antimycotic activity.
摘要
合成了一系列在环和/或磺酰胺氮上有不同甲基化且在苯环上被NO2或NH2取代的N-(5-嘧啶基)苯磺酰胺，并通过光谱法（核磁共振）进行了研究。在对几种白色念珠菌和热带念珠菌菌株进行测试时，其中一些化合物表现出非常轻微的抗真菌活性。
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