Daidone G, Raffa D, Bajardi M L, Plescia S, Milici M
Dipartimento di Chimica e Tecnologie Farmaceutiche, Universita di Palermo.
Farmaco Sci. 1988 Sep;43(9):753-61.
Novel N-(3-methyl-4-R-isoxazol-5-yl)-2-R1-4-R2-phenoxyacetamides and N-(3-methyl-4-R-isoxazol-5-yl)-2-(2-R1-4-R2-phenoxyacetamido) benzamides were prepared and tested against Candida albicans and Cryptococcus neoformans. The results of the antimicrobial assay showed that the presence of two amidic groups usually enhances antimycotic activity.
合成了新型的N-(3-甲基-4-R-异恶唑-5-基)-2-R1-4-R2-苯氧基乙酰胺和N-(3-甲基-4-R-异恶唑-5-基)-2-(2-R1-4-R2-苯氧基乙酰氨基)苯甲酰胺,并对白色念珠菌和新型隐球菌进行了测试。抗菌试验结果表明,两个酰胺基的存在通常会增强抗真菌活性。