Garuti L, Giovanninetti G, Ferranti A, Chiarini A, Bertocchi G, Sabatino P, Brigidi P
Institute of Pharmaceutical Chemistry of the University, Bologna, Italy.
Pharmazie. 1987 Jun;42(6):378-81.
Some benzyloxyimio compounds, related to oxiconazole and having a 1H-indole or 1H-benzimidazole moiety, have been synthesized and tested in vitro for their antimycotic activity against Candida tropicalis and C. albicans. The most active was showed to be 0-(2,4-dichlorobenzyl)-1-benzyl-5-nitro-1H-benzimidazole-2-carboxaldehyd e oxime (MIC: 25 micrograms/ml against both microorganisms). A structural feature important for the biological activity of the series appears to be presence of a benzimidazole nucleus substituted by an electron withdrawing group.
