Synthesis and antimycotic activity of some benzyloxyimino compounds.
作者信息
Garuti L, Giovanninetti G, Ferranti A, Chiarini A, Bertocchi G, Sabatino P, Brigidi P
机构信息
Institute of Pharmaceutical Chemistry of the University, Bologna, Italy.
出版信息
Pharmazie. 1987 Jun;42(6):378-81.
PMID:3671457
Abstract
Some benzyloxyimio compounds, related to oxiconazole and having a 1H-indole or 1H-benzimidazole moiety, have been synthesized and tested in vitro for their antimycotic activity against Candida tropicalis and C. albicans. The most active was showed to be 0-(2,4-dichlorobenzyl)-1-benzyl-5-nitro-1H-benzimidazole-2-carboxaldehyd e oxime (MIC: 25 micrograms/ml against both microorganisms). A structural feature important for the biological activity of the series appears to be presence of a benzimidazole nucleus substituted by an electron withdrawing group.
摘要
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