Giosue S, Bernocchi D, Parola D, Munno R, Mancini P
Second Pneumological Department, La Sapienza Hospital, University of Rome, Italy.
J Int Med Res. 1987 Nov-Dec;15(6):352-60. doi: 10.1177/030006058701500604.
A sustained-release theophylline preparation in capsule form was compared with standard slow-release theophylline tablets for variation in plasma theophylline concentration, effectiveness and tolerability in 30 adults with chronic broncho-obstructive pathology. They were administered every 12 h and blood samples were collected after 8 days of treatment during the steady-state period. In this double-dummy crossover study, the sequence of the two regimens (sustained-release capsules versus tablets) was selected at random. The results of this study demonstrate that plasma theophylline levels remain within the therapeutic range for both preparations. Effectiveness and tolerability of the two drugs were satisfactory.
在30名患有慢性支气管阻塞性病变的成年人中，对胶囊形式的缓释茶碱制剂与标准缓释茶碱片进行了比较，观察其血浆茶碱浓度变化、有效性和耐受性。两种制剂均每12小时给药一次，并在稳态期治疗8天后采集血样。在这项双盲交叉研究中，随机选择两种治疗方案（缓释胶囊与片剂）的给药顺序。该研究结果表明，两种制剂的血浆茶碱水平均保持在治疗范围内。两种药物的有效性和耐受性均令人满意。
