Ruggeri S, Bernocchi D, Berte F, D'Anneo R, Gramolini C
J Int Med Res. 1987 May-Jun;15(3):170-8. doi: 10.1177/030006058701500308.
The relation between serum theophylline concentrations, effectiveness, tolerability and compliance were evaluated in 14 hospitalized elderly patients with broncho-obstructive pathology, using a new twice daily sustained release theophylline suspension compared to standard twice daily slow release tablets. The results showed that the mean theophylline serum concentration remains within the therapeutic range with both preparations. No significant difference exists between the two treatments with regard to effectiveness. Tolerability and compliance of the theophylline suspension, however, were higher.
在14名患有支气管阻塞性病变的住院老年患者中，评估了血清茶碱浓度、有效性、耐受性和依从性之间的关系。使用一种新的每日两次的缓释茶碱混悬液，并与标准的每日两次缓释片剂进行比较。结果表明，两种制剂的平均血清茶碱浓度均保持在治疗范围内。两种治疗方法在有效性方面没有显著差异。然而，茶碱混悬液的耐受性和依从性更高。
