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德国一所大学医学中心内部资助计划的研究项目发表率:一项回顾性研究(2004-2013 年)。

Publication rates of research projects of an internal funding program of a university medical center in Germany: A retrospective study (2004-2013).

机构信息

Faculty of Medicine, Institute for Laboratory Animal Science & Experimental Surgery, RWTH Aachen University, Aachen, Germany.

Faculty of Medicine, Dean's Office, RWTH Aachen University, Aachen, Germany.

出版信息

PLoS One. 2020 Nov 30;15(11):e0243092. doi: 10.1371/journal.pone.0243092. eCollection 2020.

Abstract

OBJECTIVES

Non-publication and publication bias are topics of considerable importance to the scientific community. These issues may limit progress toward the 3R principle for animal research, promote waste of public resources, and generate biased interpretations of clinical outcomes. To investigate current publishing practices and to gain some understanding of the extent to which research results are reported, we examined publication rates of research projects that were approved within an internal funding program of the Faculty of Medicine at a university medical center in Germany, which is exemplary for comparable research funding programs for the promotion of young researchers in Germany and Europe.

METHODS

We analyzed the complete set (n = 363) of research projects that were supported by an internal funding program between 2004 and 2013. We divided the projects into four different proposal types that included those that required an ethics vote, those that included an animal proposal, those that included both requirements, and those that included neither requirement.

RESULTS

We found that 65% of the internally funded research projects resulted in at least one peer-reviewed publication; this increased to 73% if other research contributions were considered, including abstracts, book and congress contributions, scientific posters, and presentations. There were no significant differences with respect to publication rates based on (a) the clinic/institute of the applicant, (b) project duration, (c) scope of funding or (d) proposal type.

CONCLUSION

To the best of our knowledge, this is the first study to explore publication rates associated with early-career medical research funding. As >70% of the projects ultimately generated some form of publication, the program was overall effective toward this goal; however, non-publication of research results is still prevalent. Further research will explore the reasons underlying non-publication. We hope to use these findings to develop strategies that encourage publication of research results.

摘要

目的

不发表偏倚和发表偏倚是科学界非常关注的问题。这些问题可能会限制动物研究 3R 原则的进展,浪费公共资源,并对临床结果产生有偏差的解释。为了调查当前的发表实践,并了解研究结果报告的程度,我们检查了在德国一所大学医学中心的医学系内部资助计划内获得批准的研究项目的发表率,该中心为德国和欧洲的年轻研究人员促进类似的研究资助计划树立了典范。

方法

我们分析了 2004 年至 2013 年期间由内部资助计划资助的 363 个完整的研究项目。我们将项目分为四种不同的提案类型,包括需要伦理投票的项目、包含动物提案的项目、同时包含这两个要求的项目以及不包含这两个要求的项目。

结果

我们发现,内部资助的研究项目中有 65%至少有一篇同行评审的出版物;如果考虑其他研究贡献,包括摘要、书籍和会议贡献、科学海报和演示文稿,这一比例增加到 73%。基于以下因素,发表率没有显著差异:(a)申请人的诊所/研究所,(b)项目持续时间,(c)资助范围或(d)提案类型。

结论

据我们所知,这是第一项探索与医学研究早期职业资助相关的发表率的研究。由于 >70%的项目最终产生了某种形式的出版物,因此该计划在总体上实现了这一目标;然而,研究结果的不发表仍然很普遍。进一步的研究将探讨不发表的原因。我们希望利用这些发现制定鼓励发表研究结果的策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28f7/7703943/7f7470de8ede/pone.0243092.g001.jpg

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