Nutrition and Obesities: Systemic Approaches Research Unit (Nutriomics), Sorbonne Université, Institut National de la Santé et de la Recherche Médicale, Paris, France; Nutrition Department, Assistante Publique Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Centres de Recherche en Nutrition Humaine Ile de France, Paris, France; Department of Vascular Medicine, Amsterdam Universitair Medische Centra, location Academisch Medisch Centrum, and VUMC, University of Amsterdam, Amsterdam, the Netherlands.
Department of Vascular Medicine, Amsterdam Universitair Medische Centra, location Academisch Medisch Centrum, and VUMC, University of Amsterdam, Amsterdam, the Netherlands.
Gastroenterology. 2021 Jan;160(2):573-599. doi: 10.1053/j.gastro.2020.10.057. Epub 2020 Nov 27.
Changes in the intestinal microbiome have been associated with obesity and type 2 diabetes, in epidemiological studies and studies of the effects of fecal transfer in germ-free mice. We review the mechanisms by which alterations in the intestinal microbiome contribute to development of metabolic diseases, and recent advances, such as the effects of the microbiome on lipid metabolism. Strategies have been developed to modify the intestinal microbiome and reverse metabolic alterations, which might be used as therapies. We discuss approaches that have shown effects in mouse models of obesity and metabolic disorders, and how these might be translated to humans to improve metabolic health.
肠道微生物组的变化与肥胖和 2 型糖尿病有关，这在流行病学研究和无菌小鼠粪便转移研究中均有体现。我们综述了肠道微生物组的改变如何促进代谢性疾病的发展，以及最近的进展，如微生物组对脂质代谢的影响。人们已经开发出了改变肠道微生物组并逆转代谢改变的策略，这些策略可能被用作治疗方法。我们讨论了在肥胖和代谢紊乱的小鼠模型中显示出效果的方法，以及如何将这些方法转化为人类以改善代谢健康。
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