Herrema Hilde, IJzerman Richard G, Nieuwdorp Max
Department of Experimental Vascular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1055 AZ, Amsterdam, the Netherlands.
Department of Internal Medicine, Free University Medical Center, Amsterdam, the Netherlands.
Diabetologia. 2017 Apr;60(4):613-617. doi: 10.1007/s00125-016-4192-0. Epub 2016 Dec 24.
The role of the intestinal microbiota and microbial metabolites in the maintenance of host health and development of metabolic disease has gained significant attention over the past decade. Mechanistic insight revealing causality, however, is scarce. Work by Ussar and co-workers demonstrates that a complex interaction between microbiota, host genetics and environmental factors is involved in metabolic disease development in mice. In addition, Perry and co-workers show that the microbial metabolite acetate augments insulin resistance in rats. These studies underscore an important role of the microbiota in the development of obesity and symptoms of type 2 diabetes in rodents. If causality can be demonstrated in humans, development of novel diagnostic and therapeutic tools that target the gut microbiota will have high potential.
在过去十年中，肠道微生物群和微生物代谢产物在维持宿主健康及代谢性疾病发展中的作用已受到广泛关注。然而，揭示因果关系的机制性见解却很匮乏。乌萨尔及其同事的研究表明，微生物群、宿主基因和环境因素之间的复杂相互作用与小鼠代谢性疾病的发展有关。此外，佩里及其同事表明，微生物代谢产物乙酸盐会增强大鼠的胰岛素抵抗。这些研究强调了微生物群在啮齿动物肥胖症发展和2型糖尿病症状中的重要作用。如果能在人类中证明因果关系，那么开发针对肠道微生物群的新型诊断和治疗工具将具有很大潜力。
