抗生素或益生菌早期处理的雏鸡的氧化与表观遗传变化及肠道通透性反应
Oxidative and Epigenetic Changes and Gut Permeability Response in Early-Treated Chickens with Antibiotic or Probiotic.
作者信息
Ognik Katarzyna, Konieczka Paweł, Stępniowska Anna, Jankowski Jan
机构信息
Department of Biochemistry and Toxicology, Faculty of Animal Science and Bioeconomy, University of Life Sciences, Akademicka 13, 20-950 Lublin, Poland.
Department of Poultry Science, Faculty of Animal Bioengineering, University of Warmia and Mazury in Olsztyn, Oczapowskiego 5, 10-719 Olsztyn, Poland.
出版信息
Animals (Basel). 2020 Nov 25;10(12):2204. doi: 10.3390/ani10122204.
The aim of this study was to compare the effect of the use of enrofloxacin and a probiotic containing and strains in the first week of life of chickens on oxidative and epigenetic changes in molecules and intestinal integrity. The three treatments were as follows: the control group received no additive in the drinking water (GC); the second group (GP) received a probiotic preparation in the drinking water during the first five days of life, providing strain 4a1713 at 1.0 × 10 CFU/L water and 4b1822 at 1.0 × 10 CFU/L water, the third group (GA) received an antibiotic (enrofloxacin 0.5 mL/L water) in the drinking water during the first five days of life. The use of both enrofloxacin and a probiotic containing and strains in chickens' first week of life improved intestinal integrity and reduced inflammation and oxidative and epigenetic changes in the small intestine. This effect was evident both at 6 days of age and at the end of the rearing period.
本研究的目的是比较在雏鸡生命的第一周使用恩诺沙星和含有屎肠球菌和嗜酸乳杆菌菌株的益生菌对分子氧化和表观遗传变化以及肠道完整性的影响。三种处理方式如下：对照组在饮用水中不添加任何添加剂（GC）；第二组（GP）在雏鸡生命的前五天在饮用水中添加益生菌制剂，每升水提供1.0×10⁸CFU的屎肠球菌4a1713菌株和1.0×10⁸CFU的嗜酸乳杆菌4b1822菌株；第三组（GA）在雏鸡生命的前五天在饮用水中添加抗生素（恩诺沙星0.5 mL/L水）。在雏鸡生命的第一周使用恩诺沙星和含有屎肠球菌和嗜酸乳杆菌菌株的益生菌均可改善肠道完整性，并减少小肠中的炎症以及氧化和表观遗传变化。这种效果在6日龄和饲养期结束时均很明显。
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