腺病毒-细胞外蛋白相互作用及其对人单核吞噬细胞固有免疫应答的影响。
Adenovirus-Extracellular Protein Interactions and Their Impact on Innate Immune Responses by Human Mononuclear Phagocytes.
机构信息
Institut de Génétique Moléculaire de Montpellier, Université de Montpellier, CNRS (French National Centre for Scientific Research), 34090 Montpellier, France.
出版信息
Viruses. 2020 Nov 26;12(12):1351. doi: 10.3390/v12121351.
Abstract
The aim of this review is to highlight how, in a syngeneic system, human mononuclear phagocytes respond to environments containing human adenovirus (HAdV) and soluble extracellular proteins that influence their innate immune response. Soluble extracellular proteins, including immunoglobulins, blood clotting factors, proteins of the complement system, and/or antimicrobial peptides (AMPs) can exert direct effects by binding to a virus capsid that modifies interactions with pattern recognition receptors and downstream signaling. In addition, the presence, generation, or secretion of extracellular proteins can indirectly influence the response to HAdVs via the activation and recruitment of cells at the site of infection.
摘要
本篇综述旨在强调在同种异体系统中，人类单核吞噬细胞如何对含有人类腺病毒 (HAdV) 和影响其固有免疫反应的可溶性细胞外蛋白的环境作出反应。可溶性细胞外蛋白，包括免疫球蛋白、凝血因子、补体系统蛋白和/或抗菌肽 (AMPs)，可通过与改变与模式识别受体和下游信号转导相互作用的病毒衣壳结合而产生直接影响。此外，细胞外蛋白的存在、产生或分泌可通过感染部位细胞的激活和募集而间接影响对 HAdV 的反应。
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