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Did Dendritic Cell Activation, Induced by Adenovirus-Antibody Complexes, Play a Role in the Death of Jesse Gelsinger?

作者信息

Baker Andrew H, Herzog Roland W

机构信息

University of Edinburgh/BHF Centre for Cardiovascular Science, Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK.

Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA.

出版信息

Mol Ther. 2020 Mar 4;28(3):704-706. doi: 10.1016/j.ymthe.2020.02.010. Epub 2020 Feb 15.

DOI:10.1016/j.ymthe.2020.02.010
PMID:32061269
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7054810/
Abstract
摘要

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本文引用的文献

1
Adenovirus-Antibody Complexes Contributed to Lethal Systemic Inflammation in a Gene Therapy Trial.腺病毒-抗体复合物导致基因治疗试验中致命性全身炎症。
Mol Ther. 2020 Mar 4;28(3):784-793. doi: 10.1016/j.ymthe.2020.01.006. Epub 2020 Feb 7.
2
Humoral immune response to adenovirus induce tolerogenic bystander dendritic cells that promote generation of regulatory T cells.体液免疫反应对腺病毒诱导耐受性旁观者树突状细胞，促进调节性 T 细胞的生成。
PLoS Pathog. 2018 Aug 20;14(8):e1007127. doi: 10.1371/journal.ppat.1007127. eCollection 2018 Aug.
3
Immune-Complexed Adenovirus Induce AIM2-Mediated Pyroptosis in Human Dendritic Cells.免疫复合物型腺病毒在人树突状细胞中诱导AIM2介导的细胞焦亡。
PLoS Pathog. 2016 Sep 16;12(9):e1005871. doi: 10.1371/journal.ppat.1005871. eCollection 2016 Sep.
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Trained immunity: A program of innate immune memory in health and disease.训练有素的免疫：健康与疾病中的固有免疫记忆程序。
Science. 2016 Apr 22;352(6284):aaf1098. doi: 10.1126/science.aaf1098. Epub 2016 Apr 21.
5
Development of Novel Adenoviral Vectors to Overcome Challenges Observed With HAdV-5-based Constructs.新型腺病毒载体的研发以克服基于人5型腺病毒构建体所观察到的挑战。
Mol Ther. 2016 Feb;24(1):6-16. doi: 10.1038/mt.2015.194. Epub 2015 Oct 19.
6
Human erythrocytes bind and inactivate type 5 adenovirus by presenting Coxsackie virus-adenovirus receptor and complement receptor 1.人类红细胞通过呈现柯萨奇病毒-腺病毒受体和补体受体1来结合并使5型腺病毒失活。
Blood. 2009 Feb 26;113(9):1909-18. doi: 10.1182/blood-2008-09-178459. Epub 2009 Jan 8.
7
The cell adhesion molecule "CAR" and sialic acid on human erythrocytes influence adenovirus in vivo biodistribution.细胞黏附分子“CAR”和人红细胞上的唾液酸影响腺病毒在体内的生物分布。
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Effect of adenovirus serotype 5 fiber and penton modifications on in vivo tropism in rats.5型腺病毒纤维蛋白和五聚体修饰对大鼠体内嗜性的影响。
Mol Ther. 2004 Aug;10(2):344-54. doi: 10.1016/j.ymthe.2004.05.020.