Frias-De-Diego Alba, Posey Rachael, Pecoraro Brittany M, Fernandes Carnevale Rafaella, Beaty Alayna, Crisci Elisa
Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607, USA.
William Rand Kenan, Jr. Library of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607, USA.
Vet Sci. 2020 Nov 26;7(4):189. doi: 10.3390/vetsci7040189.
Influenza viruses (IV) are one of the major threats to human and animal health worldwide due to the variety of species they affect. Pigs play an important role in IV ecology as the "mixing vessel," since they can be infected by swine, avian and human IV, allowing the appearance of new subtypes. Human viruses originated in swine are known as IV of swine origin or swine influenza virus (SwIV) variants. In this study, we identified knowledge tendencies of SwIV and assessed potential bias in the literature caused by these variants. We identified the most mentioned SwIV variants and manually reviewed the literature to determine the number of publications applying the whole influenza nomenclature, a partial nomenclature, only the subtype or mixed terminology, along with the proportion of articles in which the GenBank ID number was available. We observed that the 2009 H1N1 human pandemic created an important bias in SwIV research driven by an increase in human publications on the IV of swine origin. H1N1 is the most studied subtype for swine and humans, followed by H3N2. We found differences between the nomenclatures applied, where partial classifications were slightly more common. Finally, from all the publications, only 25% stated the GenBank ID of the sequence studied. This review represents the most complete exploration of trends in SwIV knowledge to date and will serve as a guidance for future search strategies in SwIV research.
流感病毒（IV）因其能感染多种物种，成为全球人类和动物健康的主要威胁之一。猪在流感病毒生态中扮演着“混合容器”的重要角色，因为它们可被猪流感病毒、禽流感病毒和人流感病毒感染，从而促使新亚型出现。源自猪的人类病毒被称为猪源流感病毒或猪流感病毒（SwIV）变体。在本研究中，我们确定了猪流感病毒的知识趋势，并评估了这些变体在文献中可能造成的偏差。我们确定了被提及最多的猪流感病毒变体，并人工查阅文献，以确定使用完整流感命名法、部分命名法、仅使用亚型或混合术语的出版物数量，以及可获取GenBank ID编号的文章比例。我们观察到，2009年甲型H1N1流感大流行在猪流感病毒研究中造成了重大偏差，原因是关于猪源流感病毒的人类出版物有所增加。H1N1是针对猪和人类研究最多的亚型，其次是H3N2。我们发现所应用的命名法存在差异，部分分类更为常见。最后，在所有出版物中，只有25%注明了所研究序列的GenBank ID。本综述是迄今为止对猪流感病毒知识趋势最全面的探索，将为猪流感病毒研究未来的检索策略提供指导。
