外源性和内源性雌激素对轻度热应激体温调节反应的影响及其与光照和黑暗阶段的相互作用。
Influence of exogenous and endogenous estrogen on thermoregulatory responses to mild heat and the interaction with light and dark phases.
机构信息
Body Temperature and Fluid Laboratory, Faculty of Human Sciences, Waseda University, Mikajima 2-579-15, Tokorozawa, Saitama, 359-1192, Japan.
Graduate School of Human Sciences, Faculty of Human Sciences, Waseda University, Tokorozawa, Japan.
出版信息
J Physiol Sci. 2020 Nov 30;70(1):56. doi: 10.1186/s12576-020-00782-x.
The present study aimed to determine the influence of estradiol (E) and the interaction with circadian phases on thermoregulatory responses to mild heat in female rats. Heat loss and production during 3-h exposure to the environment at an ambient temperature of 28-34 °C were assessed by measuring abdominal temperature (T), tail skin temperature, and oxygen consumption in ovariectomized rats with and without E replacement (OVX + E and OVX, respectively) and in control rats in the proestrus (P) and diestrus (D) phases. In the light phase, T remained unchanged in all groups. T increased in the dark phase, but was lower in the OVX + E and P groups than in the OVX and D groups. Oxygen consumption decreased at 34 °C, but to a lesser extent in the OVX + E group than in the OVX group. These results suggest that E activates thermoregulation in mild heat in the dark phase.
本研究旨在确定雌二醇（E）及其与昼夜节律相位的相互作用对雌性大鼠在轻度热环境中体温调节反应的影响。通过测量腹温（T）、尾巴皮肤温度和耗氧量，评估了在环境温度为 28-34°C 下暴露 3 小时期间，去卵巢大鼠（OVX+E 和 OVX）和对照组大鼠在发情前期（P）和发情期（D）阶段的热损失和产生情况。在光照期，所有组的 T 保持不变。在暗期 T 升高，但 OVX+E 和 P 组的 T 低于 OVX 和 D 组。在 34°C 时耗氧量下降，但 OVX+E 组的下降幅度小于 OVX 组。这些结果表明，E 在暗期轻度热环境中激活体温调节。
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