Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Eye (Lond). 2021 Oct;35(10):2820-2825. doi: 10.1038/s41433-020-01321-z. Epub 2020 Nov 30.
BACKGROUND/OBJECTIVES: The prevalence of myopia is higher in preterm infants who underwent laser photocoagulation (LPC) for retinopathy of prematurity (ROP). The aim of this study was to investigate factors associated with myopia in preterm infants who undergo LPC for ROP.
SUBJECTS/METHODS: We retrospectively analysed the medical records of preterm infants born at Kyushu University Hospital (October 2008-March 2018) at ≤32 weeks of gestational age or with birth weight ≤1500 g. We evaluated the associations between nine clinical factors and the spherical equivalent at 1-year corrected age by performing multivariable linear regression in LPC-treated ROP patients.
Among the 485 infants enroled, 76 developed ROP requiring treatment. Of these, 71 underwent LPC, which was provided to 63 infants as the primary treatment (LPC alone or the combination therapy of LPC and intravitreal injection of bevacizumab [IVB]) and to eight infants as additional LPC after IVB monotherapy. The results of a refractive examination at 1-year corrected age were available for 110 eyes of 56 infants (78.9%). The mean ± standard deviation of the SE value was -0.5 ± 3.0 dioptres (D). Multivariable linear regression analysis revealed a significant association between laser spot count and SE value (ß = -0.081 ± 0.040 D per 100 spots [mean ± standard error], p = 0.045).
Our results suggest that an increased laser spot count observed during ROP treatment associates with myopia.
背景/目的：早产儿接受激光光凝（LPC）治疗早产儿视网膜病变（ROP）后，近视的患病率更高。本研究旨在探讨接受 LPC 治疗 ROP 的早产儿近视的相关因素。
我们回顾性分析了九州大学医院（2008 年 10 月至 2018 年 3 月）出生胎龄≤32 周或出生体重≤1500g 的早产儿的病历。我们通过多变量线性回归分析 LPC 治疗 ROP 患者的 9 个临床因素与 1 年矫正年龄时的球镜等效值之间的关系。
在纳入的 485 名婴儿中，有 76 名患有需要治疗的 ROP。其中，71 名婴儿接受了 LPC，63 名婴儿接受了 LPC 作为主要治疗（LPC 单独或 LPC 联合玻璃体腔内注射贝伐单抗[IVB]），8 名婴儿接受了 IVB 单药治疗后额外的 LPC。56 名婴儿（78.9%）的 110 只眼可获得 1 年矫正年龄时的屈光检查结果。SE 值的平均值±标准差为-0.5±3.0 屈光度（D）。多变量线性回归分析显示，激光光斑数与 SE 值之间存在显著关联（每 100 个光斑 SE 值的变化量为-0.081±0.040 D[平均值±标准误]，p=0.045）。
我们的结果表明，ROP 治疗过程中观察到的激光光斑数增加与近视有关。
