Pastorello E A, Incorvaia C, Vassellatti D, Qualizza R, Codecasa L R
2nd Department of Internal Medicine, University of Milan, School of Medicine, Milano, Italy.
N Engl Reg Allergy Proc. 1987 Nov-Dec;8(6):437-41. doi: 10.2500/108854187778999694.
Venom immunotherapy provides clinical protection against hymenoptera stings in almost all treated allergic patients. Venom specific IgG antibodies often rise during immunotherapy and some studies found an association between their levels and clinical protection in subjects treated with Yellow Jacket venom. It is interesting to report that, among IgG subclasses, venom specific IgG4 show the most significant increase but IgG1 could represent a relevant immunological mechanism, exerting a regulatory function on venom specific IgE levels. We observed in patients submitted to Honey Bee venom immunotherapy a significant increase of venom specific IgG1 and IgG4 antibodies, while IgG2 showed an insignificant increase only in some patients. Persistent high levels of IgG4 with respect to decreasing levels of IgG1 were observed only after prolonged treatment.
毒液免疫疗法为几乎所有接受治疗的过敏患者提供针对膜翅目昆虫叮咬的临床保护。毒液特异性IgG抗体在免疫疗法期间通常会升高，一些研究发现，在用黄胡蜂毒液治疗的受试者中，它们的水平与临床保护之间存在关联。有趣的是，在IgG亚类中，毒液特异性IgG4升高最为显著，但IgG1可能代表一种相关的免疫机制，对毒液特异性IgE水平发挥调节作用。我们观察到，接受蜜蜂毒液免疫疗法的患者中，毒液特异性IgG1和IgG4抗体显著增加，而IgG2仅在部分患者中出现不显著增加。仅在长期治疗后，才观察到相对于IgG1水平下降而言持续高水平的IgG4。
