载脂蛋白 E4 对 PHF-Tau 网络影响的研究。
A Study on PHF-Tau Network Effected by Apolipoprotein E4.
机构信息
School of Management Science and Engineering, Shandong Technology and Business University, Yantai, People's Republic of China.
School of Information Science and Engineering, Lanzhou University, Lanzhou, People's Republic of China.
出版信息
Am J Alzheimers Dis Other Demen. 2020 Jan-Dec;35:1533317520971414. doi: 10.1177/1533317520971414.
Apolipoprotein E 4 Allele (APOE 4) is an important factors in Mild cognitive impairment (MCI) and Alzheimer's disease(AD). It plays a primary role in abnormal modification of aggregated Tau protein-paired helical filaments Tau (PHF-Tau). In this study, 143 subjects with PHF-Tau PET were divided into 2 groups (APOE 4 carriers and noncarriers). The measurements of the PHF-Tau network properties and resilient were calculated for 2 group networks respectively. APOE 4 carriers group showed significant differences in all the network properties in the results. We also found significant differences of betweenness centrality in some brain regions for APOE 4 carriers. Moreover, the APOE 4 carriers showed less resilient to targeted or random node failure. Our results indicated that the effects of APOE 4 may lead to abnormalities of PHF-Tau protein network. These findings may be particularly helpful in uncovering the pathophysiology underlying the cognitive dysfunction in MCI patients.
载脂蛋白 E4 等位基因（APOE4）是轻度认知障碍（MCI）和阿尔茨海默病（AD）的重要因素。它在 Tau 蛋白聚集的异常修饰中起着主要作用——双螺旋丝 Tau（PHF-Tau）。在这项研究中，143 名 PHF-Tau PET 患者被分为 2 组（APOE4 携带者和非携带者）。分别计算了 2 组网络的 PHF-Tau 网络特性和弹性的测量值。APOE4 携带者组在结果中的所有网络特性上均显示出显著差异。我们还发现，在一些脑区，APOE4 携带者的介数中心度存在显著差异。此外，APOE4 携带者对靶向或随机节点故障的弹性较小。我们的研究结果表明，APOE4 的影响可能导致 PHF-Tau 蛋白网络的异常。这些发现可能有助于揭示 MCI 患者认知功能障碍的病理生理学基础。
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