1Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
2Department of Medical Laboratory Sciences, Arak School of Paramedicine, Arak University of Medical Sciences, Arak, Iran.
Acta Microbiol Immunol Hung. 2020 Dec 1;67(4):228-233. doi: 10.1556/030.2020.01273.
Methicillin-resistant Staphylococcus aureus (MRSA) is one of the major pathogens in Iran with a high prevalence and a high level of antibiotic resistance. Ceftaroline is a fifth generation cephalosporin binding and inhibiting penicillin binding protein (PBP2a).
In the present study, 228 clinical MRSA isolates were collected from four cities of Iran and their susceptibility to ceftaroline was evaluated by E-test and the disk diffusion method.
Our results showed a high susceptibility rate (97.3%) to ceftaroline in MRSA strains from Iran. Six isolates were found to be ceftaroline non-susceptible (CPT-NS) with Minimum inhibitory concentration (MIC) ≥2 µg/mL. All CPT-NS isolates were isolated from blood and tracheal aspirate and belonged to SCCmec type III as well as agr type I and were all susceptible to vancomycin. Out of six isolates, three, two and one belonged to spa type t030, t4864, and t969, respectively. Vancomycin, quinupristin/dalfopristin, linezolid, chloramphenicol, and tigecycline were the most active agents against CPT-NS isolates.
Due to the broad-spectrum activity and low toxicity of ceftaroline as well as the increased rate of vancomycin resistance among MRSA strains in recent years, ceftaroline can be considered as a novel approach to treat MRSA-induced infections.
耐甲氧西林金黄色葡萄球菌（MRSA）是伊朗的主要病原体之一，具有较高的流行率和抗生素耐药水平。头孢洛林是一种第五代头孢菌素，可结合并抑制青霉素结合蛋白（PBP2a）。
本研究从伊朗四个城市收集了 228 株临床 MRSA 分离株，采用 E 试验和纸片扩散法评估头孢洛林的药敏性。
我们的结果显示，伊朗的 MRSA 菌株对头孢洛林具有很高的敏感性（97.3%）。有 6 株分离株对头孢洛林表现出耐药性（CPT-NS），最低抑菌浓度（MIC）≥2µg/mL。所有 CPT-NS 分离株均来自血液和气管抽吸物，属于 SCCmec 型 III，agr 型 I，均对万古霉素敏感。在这 6 株分离株中，有 3、2 和 1 株分别属于 spa 型 t030、t4864 和 t969。万古霉素、奎奴普丁/达福普汀、利奈唑胺、氯霉素和替加环素是对 CPT-NS 分离株最有效的药物。
由于头孢洛林具有广谱活性、低毒性，且近年来 MRSA 菌株对万古霉素的耐药率不断上升，头孢洛林可作为治疗 MRSA 感染的新方法。
