Department of Microbiology Believers Church Medical College, Thiruvalla, Kerala, India.
Ethiop J Health Sci. 2023 Jan;33(1):143-150. doi: 10.4314/ejhs.v33i1.18.
Methicillin-resistant Staphylococcus aureus (MRSA) is an important bacterial pathogen causing a number of community-acquired and nosocomial infections. Ceftaroline fosamil is a fifth generation cephalosporin, approved for the treatment of infections caused by MRSA. The main objective of this study was to estimate the susceptibility of ceftaroline among isolates of MRSA by using CLSI and EUCAST breakpoints.
Fifty non-duplicate isolates of MRSA were included in the study. Ceftaroline susceptibility was done using E-strip test and interpreted using CLSI and EUCAST breakpoints.
Susceptible isolates were equal (42%) by both CLSI and EUCAST, while resistant isolates were more commonly seen in EUCAST (50%). Ceftaroline MIC ranged from 0.25- >32µg/ml. All the isolates were sensitive to Teicoplanin and Linezolid.
Resistant isolates were less (30%) while using the CLSI 2021 criteria probably due to the inclusion of SDD category. Our study showed that Fourteen isolates (28%) had Ceftaroline MIC >32µg/ml, which is an alarming finding. The high percentage of Ceftaroline resistant isolates in our study probably suggest a hospital spread of Ceftaroline resistant MRSA emphasizing the need for stringent infection control precautions.
耐甲氧西林金黄色葡萄球菌（MRSA）是一种重要的细菌病原体，可引起许多社区获得性和医院获得性感染。头孢洛林酯是一种第五代头孢菌素，已被批准用于治疗由 MRSA 引起的感染。本研究的主要目的是使用 CLSI 和 EUCAST 折点来估计头孢洛林对 MRSA 分离株的敏感性。
本研究纳入了 50 株非重复的 MRSA 分离株。使用 E-strip 试验进行头孢洛林敏感性检测，并使用 CLSI 和 EUCAST 折点进行解释。
CLSI 和 EUCAST 均显示敏感分离株的比例相等（42%），而 EUCAST 更常见耐药分离株（50%）。头孢洛林 MIC 范围为 0.25- >32µg/ml。所有分离株均对替考拉宁和利奈唑胺敏感。
使用 CLSI 2021 标准时，耐药分离株较少（30%），这可能是由于包含 SDD 类别。我们的研究表明，14 株（28%）分离株的头孢洛林 MIC>32µg/ml，这是一个令人警惕的发现。我们研究中头孢洛林耐药分离株的高比例可能表明头孢洛林耐药 MRSA 在医院内传播，强调需要采取严格的感染控制预防措施。
