Department of Pharmacology, Pharmacy and Pharmaceutical Technology, I+D Farma group (GI-1645), Faculty of Pharmacy, Health Research Institute of Santiago de Compostela (IDIS), Agrupación Estratégica de Materiales (AeMAT), Universidade de Santiago de Compostela, Santiago de Compostela E-15782, Spain.
Laboratory of Foodomics, Institute of Food Science Research, CIAL, CSIC, Nicolás Cabrera 9, Madrid 28049, Spain.
Biomacromolecules. 2020 Dec 14;21(12):5336-5344. doi: 10.1021/acs.biomac.0c01414. Epub 2020 Dec 1.
Starch aerogels are attractive materials for biomedical applications because of their low density and high open porosity coupled with high surface areas. However, the lack of macropores in conventionally manufactured polysaccharide aerogels is a limitation to their use as scaffolds for regenerative medicine. Moreover, the stability under storage of polysaccharide aerogels is critical for biomedical purposes and scarcely studied so far. In this work, the induction of a new macropore population (1-2 μm) well integrated into the starch aerogel backbone was successfully achieved by the incorporation of zein as a porogen. The obtained dual-porous aerogels were evaluated in terms of composition as well as morphological, textural, and mechanical properties. Stability of aerogels upon storage mimicking the zone II (25 °C, 65% relative humidity) according to the International Council for Harmonization guideline of climatic conditions was checked after 1 and 3 months from morphological, physicochemical, and mechanical perspectives. Zein incorporation induced remarkable changes in the mechanical performance of the end aerogel products and showed a preventive effect on the morphological changes during the storage period.
淀粉气凝胶因其低密度、高开孔率和高比表面积而成为生物医学应用的有吸引力的材料。然而，传统制造的多糖气凝胶中缺乏大孔限制了它们作为再生医学支架的应用。此外，多糖气凝胶在储存条件下的稳定性对于生物医学目的至关重要，但迄今为止研究甚少。在这项工作中，通过加入玉米醇溶蛋白作为造孔剂，成功地在淀粉气凝胶骨架中引入了新的大孔群体（1-2μm）。所得到的双孔气凝胶在组成以及形态、结构和机械性能方面进行了评估。根据国际协调理事会关于气候条件的指导原则，模拟区域 II（25°C，65%相对湿度）的储存稳定性在 1 个月和 3 个月后从形态、物理化学和机械角度进行了检查。玉米醇溶蛋白的加入显著改变了最终气凝胶产品的机械性能，并在储存期间对形态变化表现出预防作用。
