钯催化 C(sp 2 )-H 硝氧化反应：使用正丁基硝和分子氧。
Palladium-Catalyzed C(sp)-H Nitrooxylation with -Butyl Nitrite and Molecular Oxygen.
机构信息
Department of Chemistry, Zhejiang University, Hangzhou 310027, People's Republic of China.
School of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529020, People's Republic of China.
出版信息
Org Lett. 2020 Dec 18;22(24):9719-9723. doi: 10.1021/acs.orglett.0c03794. Epub 2020 Dec 1.
Herein, we report a Pd(II)-catalyzed nitrooxylation of unactivated methyl C(sp)-H bonds using commercial available and easily manageable -butyl nitrite as the precursor of ONO radical under aerobic conditions. Environmentally benign molecular oxygen is used to initiate the generation of active radical reactant; it is also used as the terminal oxidant. A broad range of nitrooxylated aliphatic carboxamides were prepared in moderate to good yields under mild conditions.
本文报道了在 Pd(II)催化下，在有氧条件下，以商业易得且易于操作的 - 丁基硝作为 ONO 自由基前体，对未活化的甲基 C(sp)-H 键进行硝氧化反应。环境友好的分子氧用于引发活性自由基反应物的生成，同时它也作为终端氧化剂。在温和条件下，以中等到良好的收率制备了广泛的硝氧化脂肪族酰胺类化合物。
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