氟喹诺酮类药物在慢性化脓性中耳炎中的应用。

The use of fluoroquinolones in chronic otitis suppurativa.

作者信息

van de Heyning P H, Pattyn S R, Valcke H D, van Caekenberghe D L, Claes J

机构信息

Department of Otolaryngology and Head and Neck Surgery, University Hospital Antwerp, University of Antwerp, Belgium.

出版信息

Pharm Weekbl Sci. 1987 Dec 11;9 Suppl:S87-9. doi: 10.1007/BF02075270.

DOI:10.1007/BF02075270

PMID:3325935

Abstract

The present review covers fluoroquinolone usage in chronic otitis suppurativa (COS) in case of chronic otitis media, cholesteatoma, radical mastoid cavity infection and chronic or relapsing otitis externa. A total of six publications were included in the final evaluation. Enoxacin was effective in 35%; ciprofloxacin (five publications) was used in 82 patients with 67% effectivity in otitis externa and otitis media and 61% effectivity in radical mastoid cavity infection. No serious adverse reactions were reported. The promising efficacy of otitis media and otitis externa and safety profile needs further confirmation in double blind prospective clinical studies, that will provide a firm basis for changing the current treatment schedules of COS.

摘要

本综述涵盖了氟喹诺酮类药物在慢性化脓性中耳炎（COS）中的应用情况，这些病例包括慢性中耳炎、胆脂瘤、乳突根治腔感染以及慢性或复发性外耳道炎。最终评估共纳入了6篇文献。依诺沙星的有效率为35%；环丙沙星（5篇文献）应用于82例患者，在外耳道炎和中耳炎中的有效率为67%，在乳突根治腔感染中的有效率为61%。未报告严重不良反应。中耳炎和外耳道炎的良好疗效及安全性需要在双盲前瞻性临床研究中进一步证实，这将为改变COS目前的治疗方案提供坚实依据。