环丙沙星，一种对需氧菌和厌氧菌均有活性的喹诺酮羧酸化合物。
Ciprofloxacin, a quinolone carboxylic acid compound active against aerobic and anaerobic bacteria.
作者信息
Chin N X, Neu H C
出版信息
Antimicrob Agents Chemother. 1984 Mar;25(3):319-26. doi: 10.1128/AAC.25.3.319.
Abstract
The in vitro activity of ciprofloxacin, a quinolone-carboxylic acid derivative, was compared with those of norfloxacin, cefotaxime, cephalexin, ceftazidime, moxalactam, amoxicillin, and methicillin and other agents, as appropriate. The MICs of ciprofloxacin for 90% of members of the family Enterobacteriaceae and for Pseudomonas aeruginosa, Neisseria spp., and Bacteroides fragilis were between 0.005 and 0.8 micrograms/ml, whereas streptococci and staphylococci were all inhibited by less than or equal to 6.3 micrograms/ml. Ciprofloxacin was 4- to 32-fold more active than norfloxacin and inhibited gentamicin-, ameikacin-, cefotaxime-, and moxalactam-resistant members of the family Enterobacteriaceae and P. aeruginosa and methicillin-resistant Staphylococcus aureus. The activity of ciprofloxacin was not affected by serum but decreased in the presence of acid urine. The frequency of resistance to ciprofloxacin was between 10(-7) and 10(-9).
摘要
将喹诺酮羧酸衍生物环丙沙星的体外活性与诺氟沙星、头孢噻肟、头孢氨苄、头孢他啶、拉氧头孢、阿莫西林、甲氧西林及其他相关药物的活性进行了比较。环丙沙星对90%的肠杆菌科菌属以及铜绿假单胞菌、奈瑟菌属和脆弱拟杆菌的最低抑菌浓度（MIC）在0.005至0.8微克/毫升之间，而链球菌和葡萄球菌均被小于或等于6.3微克/毫升的浓度所抑制。环丙沙星的活性比诺氟沙星高4至32倍，并且能抑制对庆大霉素、阿米卡星、头孢噻肟和拉氧头孢耐药的肠杆菌科菌属及铜绿假单胞菌，以及耐甲氧西林金黄色葡萄球菌。环丙沙星的活性不受血清影响，但在酸性尿液中活性会降低。对环丙沙星的耐药频率在10^(-7)至10^(-9)之间。
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本文引用的文献
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In vitro activity of ciprofloxacin, norfloxacin and nalidixic acid.环丙沙星、诺氟沙星和萘啶酸的体外活性。
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In vitro activity of Bay 09867, a new quinoline derivative, compared with those of other antimicrobial agents.新型喹啉衍生物Bay 09867与其他抗菌药物的体外活性比较。
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