Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Pharmacol Ther. 2021 May;221:107753. doi: 10.1016/j.pharmthera.2020.107753. Epub 2020 Nov 28.
Tumor microenvironment denotes the non-cancerous cells and components presented in the tumor, including molecules produced and released by them. The constant interactions between tumor cells and the tumor microenvironment play decisive roles in tumor initiation, progression, metastasis, and response to therapies. The tumor microenvironment as a therapeutic target in cancer has attracted great research and clinical interest. Here we summarize the current progress in targeting the tumor microenvironment in both drug development and clinical trials; highlight challenges in targeting the tumor microenvironment to achieve therapeutic efficacy; explore new technologies and approaches to better decipher the tumor microenvironment; and discuss strategies to intervene in the pro-tumor microenvironment and maximize therapeutic benefits.
肿瘤微环境是指肿瘤中存在的非癌细胞和成分，包括它们产生和释放的分子。肿瘤细胞与肿瘤微环境之间的持续相互作用在肿瘤的发生、进展、转移和对治疗的反应中起着决定性的作用。肿瘤微环境作为癌症治疗的靶点，引起了广泛的研究和临床关注。在这里，我们总结了目前在药物开发和临床试验中靶向肿瘤微环境的进展；强调了靶向肿瘤微环境以实现治疗效果所面临的挑战；探讨了利用新技术和方法更好地解析肿瘤微环境的方法；并讨论了干预促肿瘤微环境和最大化治疗效益的策略。
